H
Harry A. Drabkin
Researcher at Medical University of South Carolina
Publications - 205
Citations - 13845
Harry A. Drabkin is an academic researcher from Medical University of South Carolina. The author has contributed to research in topics: Chromosomal translocation & Chromosome 3. The author has an hindex of 62, co-authored 205 publications receiving 13231 citations. Previous affiliations of Harry A. Drabkin include University of South Carolina & University of Colorado Boulder.
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Journal ArticleDOI
Nivolumab for Metastatic Renal Cell Carcinoma: Results of a Randomized Phase II Trial
Robert J. Motzer,Brian I. Rini,David F. McDermott,Bruce G. Redman,Timothy M. Kuzel,Michael R. Harrison,Ulka N. Vaishampayan,Harry A. Drabkin,Saby George,Theodore F. Logan,Kim Margolin,Elizabeth R. Plimack,Alexandre Lambert,Ian M. Waxman,Hans J. Hammers +14 more
TL;DR: Nivolumab demonstrated antitumor activity with a manageable safety profile across the three doses studied in mRCC, and no dose-response relationship was detected as measured by PFS.
Journal ArticleDOI
Cloning of the SCA7 gene reveals a highly unstable CAG repeat expansion
Gilles David,Nacer Abbas,Giovanni Stevanin,Alexandra Durr,Gaël Yvert,Géraldine Cancel,Chantal Weber,Georges Imbert,Frédéric Saudou,Eric Antoniou,Harry A. Drabkin,Robert M. Gemmill,Paola Giunti,Ali Benomar,Nicholas W. Wood,Merle Ruberg,Yves Agid,Jean-Louis Mandel,Alexis Brice +18 more
TL;DR: Gonadal instability in SCA7 is greater than that observed in any of the seven known neuro-degenerative diseases caused by translated CAG repeat expansions, and is markedly associated with paternal transmissions.
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Identification of breakpoints in t(8;21) acute myelogenous leukemia and isolation of a fusion transcript, AML1/ETO, with similarity to Drosophila segmentation gene, runt.
P. Erickson,J Gao,KS Chang,T Look,E Whisenant,S Raimondi,Robert S. Lasher,Jennifer M. Trujillo,J Rowley,Harry A. Drabkin +9 more
TL;DR: A restriction map of the chromosome 21 breakpoint region involved in t(8;21)(q22;q22.3) acute myelogenous leukemia (AML) is developed and a genomic junction clone containing chromosome 8 and 21 material is isolated.
Journal ArticleDOI
Von Hippel–Lindau disease maps to the region of chromosome 3 associated with renal cell carcinoma
Bernd R. Seizinger,Guy A. Rouleau,Laurie J. Ozelius,A.H. Lane,G. E. Farmer,J M Lamiell,Jonathan Haines,J. W M Yuen,D. Collins,Danielle Majoor-Krakauer,Tom I. Bonner,Christopher G. Mathew,Allan E. Rubenstein,John J. Halperin,Allyn McConkie-Rosell,Jane Green,James A. Trofatter,Bruce A.J. Ponder,L. Eierman,M. I. Bowmer,R. Schimke,Ben A. Oostra,Neil Aronin,David I. Smith,Harry A. Drabkin,M. H. Waziri,Wendy Hobbs,Robert L. Martuza,P. M. Conneally,Y. E. Hsia,James F. Gusella +30 more
TL;DR: The VHL gene is linked to the locus encoding the human homologoue of the RAF1 oncogene, which maps to chromosome 3p25 (ref. 4), which suggests that the defect responsible for the VHL phenotype is not a mutation in the RAF 1 gene itself.
Journal ArticleDOI
Restoring E-cadherin expression increases sensitivity to epidermal growth factor receptor inhibitors in lung cancer cell lines.
Samir E. Witta,Robert M. Gemmill,Fred R. Hirsch,Christopher D. Coldren,Karla J. Hedman,Larisa Ravdel,Barbara Helfrich,Rafal Dziadziuszko,Rafal Dziadziuszko,Daniel C. Chan,Michio Sugita,Zeng Chan,Anna E. Barón,Wilbur A. Franklin,Harry A. Drabkin,Luc Girard,Adi F. Gazdar,John D. Minna,Paul A. Bunn +18 more
TL;DR: Combined HDAC inhibitor and gefitinib treatment represents a novel pharmacologic strategy for overcoming resistance to EGFR inhibitors in patients with lung cancer.