Gaëlle Augier

TL;DR: An exclusive choice procedure is established in which ~15% of outbred rats chose alcohol over a high-value reward, including high motivation to obtain alcohol and pursuit of this drug despite adverse consequences, and may offer targets for new pharmacotherapies for treating this disorder.

TL;DR: The beneficial effects of FAAH inhibition on fear extinction, as well as stress- and affect-related behaviors, provide a strong rationale for developing this drug class as a treatment for posttraumatic stress disorder.

TL;DR: It is suggested that AEA signaling can temper aspects of the stress response and that FAAH inhibition may aid the treatment for stress-related psychiatric disorders, such as PTSD.

TL;DR: Clinical development of CERC-501 for alcohol use disorders, in particular for patients with negatively reinforced, stress-driven alcohol seeking and use, is supported by its demonstrated preclinical and clinical safety profile.

TL;DR: Findings contribute support for the notion that positive allosteric modulators of mGluR2 block relapse-like behavior across different drug categories, as well as providing evidence for a causal role of mD8529 in cue-induced relapse to alcohol seeking.