G
Gaétan Roy
Researcher at Laval University
Publications - 37
Citations - 2610
Gaétan Roy is an academic researcher from Laval University. The author has contributed to research in topics: Leishmania & Leishmania infantum. The author has an hindex of 25, co-authored 37 publications receiving 2427 citations. Previous affiliations of Gaétan Roy include McGill University.
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Journal ArticleDOI
A novel antifolate resistance gene on the amplified H circle of Leishmania.
TL;DR: The results support the hypothesis that the H region of the Leishmania genome contains several drug resistance genes and that preferential amplification of this region has evolved as a defense mechanism against cytotoxic drugs.
Journal ArticleDOI
Episomal and stable expression of the luciferase reporter gene for quantifying Leishmania spp. infections in macrophages and in animal models.
Gaétan Roy,Carole Dumas,Denis Sereno,Ying Wu,Ajay K. Singh,Michel J. Tremblay,Marc Ouellette,Martin Olivier,Barbara Papadopoulou +8 more
TL;DR: LUC-expressing recombinant parasites were useful to monitor Leishmania spp.
Journal ArticleDOI
Genome sequencing of the lizard parasite Leishmania tarentolae reveals loss of genes associated to the intracellular stage of human pathogenic species
Frédéric Raymond,Sébastien Boisvert,Gaétan Roy,Jean-François Ritt,Danielle Légaré,Amandine Isnard,Mario Stanke,Martin Olivier,Michel J. Tremblay,Barbara Papadopoulou,Marc Ouellette,Jacques Corbeil +11 more
TL;DR: The Leishmania tarentolae Parrot-TarII strain genome sequence was resolved to an average 16-fold mean coverage by next-generation DNA sequencing technologies, and its gene content appears better adapted to the promastigote insect stage rather than the amastigotes mammalian stage.
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Role of ABC transporter MRPA, γ-glutamylcysteine synthetase and ornithine decarboxylase in natural antimony-resistant isolates of Leishmania donovani
Angana Mukherjee,Prasad K. Padmanabhan,Sushma Singh,Gaétan Roy,Isabelle Girard,Mitali Chatterjee,Marc Ouellette,Rentala Madhubala +7 more
TL;DR: A variety of resistance mechanisms to SAG, most of them consistent with a model based on the study of resistance in vitro, were present in clinical isolates from the same geographical region.
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Antimony Uptake Systems in the Protozoan Parasite Leishmania and Accumulation Differences in Antimony-Resistant Parasites
Christian Brochu,Jingyu Wang,Gaétan Roy,Nadine Messier,Xiao-Yan Wang,Nancy G. Saravia,Marc Ouellette +6 more
TL;DR: In contrast to metal susceptibility, resistance to Sb(III) correlated well with decreased antimony accumulation and highlights the importance of transport systems in drug resistance of this protozoan parasite.