P
Prasad K. Padmanabhan
Researcher at Laval University
Publications - 23
Citations - 882
Prasad K. Padmanabhan is an academic researcher from Laval University. The author has contributed to research in topics: Trypanothione & Lactoylglutathione lyase. The author has an hindex of 14, co-authored 22 publications receiving 757 citations. Previous affiliations of Prasad K. Padmanabhan include Harvard University & Jawaharlal Nehru University.
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Journal ArticleDOI
Infected erythrocyte-derived extracellular vesicles alter vascular function via regulatory Ago2-miRNA complexes in malaria
Pierre-Yves Mantel,Daisy Hjelmqvist,Michael Walch,Solange Kharoubi-Hess,Sandra K. Nilsson,Deepali Ravel,Marina Ribeiro,Christof Grüring,Siyuan Ma,Prasad K. Padmanabhan,Alexander J. Trachtenberg,Johan Ankarklev,Nicolas M. B. Brancucci,Nicolas M. B. Brancucci,Curtis Huttenhower,Manoj T. Duraisingh,Ionita Ghiran,Winston Patrick Kuo,Luis Filgueira,Roberta Martinelli,Matthias Marti,Matthias Marti +21 more
TL;DR: These findings provide a mechanistic link between EVs and vascular dysfunction during malaria infection and show that EVs are efficiently internalized by endothelial cells, where the miRNA-Argonaute 2 complexes modulate target gene expression and barrier properties.
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Role of ABC transporter MRPA, γ-glutamylcysteine synthetase and ornithine decarboxylase in natural antimony-resistant isolates of Leishmania donovani
Angana Mukherjee,Prasad K. Padmanabhan,Sushma Singh,Gaétan Roy,Isabelle Girard,Mitali Chatterjee,Marc Ouellette,Rentala Madhubala +7 more
TL;DR: A variety of resistance mechanisms to SAG, most of them consistent with a model based on the study of resistance in vitro, were present in clinical isolates from the same geographical region.
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Transcriptome Remodeling in Trypanosoma cruzi and Human Cells during Intracellular Infection
Yuan Li,Sheena Shah-Simpson,Kwame Okrah,A. Trey Belew,Jungmin Choi,Kacey L. Caradonna,Prasad K. Padmanabhan,David Ndegwa,M. Ramzi Temanni,Héctor Corrada Bravo,Najib M. El-Sayed,Barbara A. Burleigh +11 more
TL;DR: The findings suggest that transcriptome remodeling is required to establish a modified template to guide developmental transitions in the parasite, whereas homeostatic functions are regulated independently of transcriptomic changes, similar to that reported in related trypanosomatids.
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Roles for mitochondria in pentamidine susceptibility and resistance in Leishmania donovani.
Angana Mukherjee,Prasad K. Padmanabhan,Mayurbhai H. Sahani,Michael P. Barrett,Rentala Madhubala +4 more
TL;DR: It was demonstrated that wild-type cells, but not resistant cells, could continue to accumulate pentamidine after apparent saturation via the measured transporter had been reached, and resistance topentamidine in L. donovani is associated with alterations to the mitochondria of the parasites, which lead to reduced accumulation of drug.
Journal ArticleDOI
Glyoxalase I from Leishmania donovani: a potential target for anti-parasite drug.
Prasad K. Padmanabhan,Angana Mukherjee,Sushma Singh,Swati Chattopadhyaya,Venkataraman S. Gowri,Peter J. Myler,Narayanaswamy Srinivasan,Rentala Madhubala +7 more
TL;DR: Comparative modelling of the 3-D structure of LDGLOI shows that substrate-binding region of the model involves important differences compared to the homologue, such as E. coli, specific to glutathione.