Galen H. Fisher

TL;DR: The occurrence of Fas mutations together with abnormal T cell apoptosis in ALPS patients suggests an involvement of Fas in this recently recognized disorder of lymphocyte homeostasis and peripheral self-tolerance.

TL;DR: It is shown that tumour necrosis factor (TNF) can mediate mature T-cell receptor-induced apoptosis through the p75 TNF receptor and suggest that autoregulatory apoptosis of the mature T cells can occur by two distinct molecular mechanisms.

TL;DR: Transgenic mice that express murine K-Ras4b(G12D) under the control of doxycycline in type II pneumocytes show that the appearance and regression of these pulmonary tumors can be readily monitored in anesthetized transgenic animals by magnetic resonance imaging.

TL;DR: It is suggested that intracytoplasmic CD95 mutations in ALPS impair apoptosis chiefly by disrupting death-domain interactions with the signaling protein FADD/MORT1.

TL;DR: To develop models of human cancer, the avian retroviral receptor, TVA, is expressed under a variety of mammalian promoters in transgenic mice, thus rendering mice susceptible to infection with avian leukosis virus-derived gene vectors.