Galina F. Makhaeva

TL;DR: Recent genetic findings with the historical body of toxicological data indicating that inhibition and aging of NTE are both necessary in order to produce neuropathy from exposure to certain OP compounds need to be reconciled.

TL;DR: A group of original compounds that combine in one molecule γ-carboline fragment of dimebon and phenothiazine core of methylene blue linked by 1-oxo- and 2-hydroxypropylene spacers emerge as promising safe multitarget ligands for the further development of a therapeutic approach against aging-related neurodegenerative disorders such as Alzheimer and/or other pathological conditions.

TL;DR: The Hansch model showed that increasing neuropathic potential correlated with rising R hydrophobicity; moreover, OPC binding to scavenger EOHs (BChE and CaE) had different effects on potential acute and delayed neurotoxicity.

TL;DR: In this paper, the proportions of these enzymes activities differed significantly and the most significant were cholinesterase activities in humans, while in rats and mice the contribution of carboxylesterase activity was the greatest.

TL;DR: The results indicate that a new series of N,N-disubstituted 2-aminothiazolines could serve as BChE and CaE inhibitors for potential medicinal applications.