Gaojie Yang

TL;DR: The current work suggests that the functionally biomimetic membranes with specific biomineralized micropatterns can be a promising alternative to periosteal autografts, with great potential for bench-to-bedside translation in orthopedics.

TL;DR: The current study provides not only a feasible and promising scaffold candidate to enhance the vascularized bone regeneration, but also a general strategy to overcome the inadequate vascularization issue for the repair of other tissue and organs.

TL;DR: A novel chimeric molecular template made of two proteins, silk fibroin and albumin, which serve as a promoter and an inhibitor for hydroxyapatite (HA) formation, respectively, to synthesize HA nanoparticles with controlled shapes suggests that a chimeric combination of promoter and inhibitor proteins is a promising approach to tuning the shape of nanoparticles.

TL;DR: It is shown that induced repair in a rabbit model of weight-bearing bone defects is greatly enhanced using a bioenergetic-active material (BAM) scaffold compared to commercialized poly(lactic acid) and calcium phosphate ceramic scaffolds.

TL;DR: In this article, a modified liquid-solution-solid (LSS) method was used to synthesize hydroxyapatite NPs with well-defined morphologies, which showed differential effects on stem cell behaviors such as particle uptake, autophagy activation and osteogenic differentiation.