G
Gareth E. Jones
Researcher at King's College London
Publications - 163
Citations - 10411
Gareth E. Jones is an academic researcher from King's College London. The author has contributed to research in topics: Podosome & Actin cytoskeleton. The author has an hindex of 55, co-authored 161 publications receiving 9816 citations. Previous affiliations of Gareth E. Jones include Randall Division of Cell and Molecular Biophysics & Ludwig Institute for Cancer Research.
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Journal ArticleDOI
A Role for Cdc42 in Macrophage Chemotaxis
TL;DR: It is concluded that Rho and Rac are required for the process of cell migration, whereas Cdc42 is required for cells to respond to a gradient of CSF-1 but is not essential for cell locomotion.
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Bayesian localization microscopy reveals nanoscale podosome dynamics
Susan Cox,Edward Rosten,James Monypenny,Tijana Jovanovic-Talisman,Dylan T. Burnette,Jennifer Lippincott-Schwartz,Gareth E. Jones,Rainer Heintzmann,Rainer Heintzmann +8 more
TL;DR: A localization microscopy analysis method that is able to extract results in live cells using standard fluorescent proteins and xenon arc lamp illumination and was able to reveal the nanoscale dynamics of podosome formation and dissociation throughout an entire cell with a resolution of 50 nm on a 4-s timescale.
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Rho, Rac and Cdc42 regulate actin organization and cell adhesion in macrophages
TL;DR: It is concluded that in Bac1 macrophages Cdc42, Rac and Rho regulate the formation of distinct actin filament-based structures, and that CDC42 and Rac are also required for the assembly of adhesion sites to the extracellular matrix.
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Pericytes support neutrophil subendothelial cell crawling and breaching of venular walls in vivo
Doris Proebstl,Mathieu-Benoit Voisin,Abigail Woodfin,James R. Whiteford,Fulvio D'Acquisto,Gareth E. Jones,David J Rowe,Sussan Nourshargh +7 more
TL;DR: After transendothelial cell migration, neutrophils actively crawl along pericyte processes before exiting the venular wall via selected gaps between adjacent pericytes.
Journal ArticleDOI
Configuration of human dendritic cell cytoskeleton by Rho GTPases, the WAS protein, and differentiation.
TL;DR: Microinjection studies indicate that podosome assembly and polarization require concerted action of Cdc42, Rac, and Rho, thereby providing a link between sequential protrusive and adhesive activity.