G
Gareth Hughes
Researcher at Novartis
Publications - 29
Citations - 1900
Gareth Hughes is an academic researcher from Novartis. The author has contributed to research in topics: Pasireotide & Cushing's disease. The author has an hindex of 14, co-authored 28 publications receiving 1324 citations. Previous affiliations of Gareth Hughes include University of Leeds & Leeds Community Healthcare NHS Trust.
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Journal ArticleDOI
Overall Survival with Ribociclib plus Endocrine Therapy in Breast Cancer
Seock-Ah Im,Yen-Shen Lu,Aditya Bardia,Nadia Harbeck,Marco Colleoni,Fabio Franke,Louis W.C. Chow,Joohyuk Sohn,Keun-Seok Lee,Saúl Campos-Gómez,Rafael Villanueva-Vazquez,Kyung Hae Jung,Arunava Chakravartty,Gareth Hughes,Ioannis Gounaris,Karen Rodriguez-Lorenc,Tetiana Taran,Sara A. Hurvitz,Debu Tripathy +18 more
TL;DR: This trial showed significantly longer overall survival with a CDK4/6 inhibitor plus endocrine therapy than with endocrine Therapy alone among patients with advanced hormone-receptor-positive, HER2-negative breast cancer.
Journal ArticleDOI
Ribociclib plus endocrine therapy for premenopausal women with hormone-receptor-positive, advanced breast cancer (MONALEESA-7): a randomised phase 3 trial
Debu Tripathy,Seock-Ah Im,Marco Colleoni,Fabio Franke,Aditya Bardia,Nadia Harbeck,Sara A. Hurvitz,Louis W.C. Chow,Joohyuk Sohn,Keun Seok Lee,Saúl Campos-Gómez,Rafael Villanueva Vazquez,Kyung Hae Jung,K Govind Babu,Paul Wheatley-Price,Michelino De Laurentiis,Young-Hyuck Im,Sherko Kuemmel,Nagi S. El-Saghir,Mei Ching Liu,Gary Carlson,Gareth Hughes,I Diaz-Padilla,C. Germa,Samit Hirawat,Yen-Shen Lu +25 more
TL;DR: In this paper, ribociclib plus endocrine therapy showed improved progression-free survival compared with letrozole alone as first-line treatment for postmenopausal patients with hormone receptor (HR)-positive, HER2-negative, advanced breast cancer.
Journal ArticleDOI
A multivariate von mises distribution with applications to bioinformatics
TL;DR: In this paper, a multivariate extension of the bivariate model of Singh, Hnizdo & Demchuk (2002) is presented, where moments and pseudo-likelihood are considered for the estimation of parameters of the new distribution.
Journal ArticleDOI
Pasireotide treatment significantly improves clinical signs and symptoms in patients with Cushing's disease: results from a Phase III study
Rosario Pivonello,Stephan Petersenn,John Newell-Price,James W. Findling,Feng Gu,Mario Maldonado,Andrew Trovato,Gareth Hughes,Luiz Roberto Salgado,André Lacroix,Jochen Schopohl,Beverly M. K. Biller +11 more
TL;DR: This analysis evaluated the effect of pasireotide treatment on signs and symptoms in patients with Cushing's disease and found it to be beneficial.
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Maximum likelihood estimation using composite likelihoods for closed exponential families
TL;DR: In this paper, the authors investigated the use of composite likelihoods instead of the full likelihood for directional data based on a bivariate von Mises distribution and showed that the parameter estimate obtained by maximizing a composite likelihood can be viewed as an approximation to the full maximum likelihood estimate.