G
Garth L. Nicolson
Researcher at University of Helsinki
Publications - 237
Citations - 23832
Garth L. Nicolson is an academic researcher from University of Helsinki. The author has contributed to research in topics: Cell culture & Membrane. The author has an hindex of 65, co-authored 228 publications receiving 23086 citations. Previous affiliations of Garth L. Nicolson include Salk Institute for Biological Studies & The New School.
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Tumor metastasis‐associated human MTA1 gene: Its deduced protein sequence, localization, and association with breast cancer cell proliferation using antisense phosphorothioate oligonucleotides
Akihiro Nawa,Katsuhiko Nishimori,Paul Lin,Yoshiyuki Maki,Kennsuke Moue,Hidetomo Sawada,Yasushi Toh,Kikkawa Fumitaka,Garth L. Nicolson +8 more
TL;DR: The results suggest that the MTA1 protein may function in cellular signaling processes important in the progression and growth of cancer cells, possibly as a nuclear regulatory factor.
Journal Article
Differences in the Sensitivities of Murine Metastatic Lymphoma/Lymphosarcoma Variants to Macrophage-mediated Cytolysis and/or Cytostasis
Karen M. Miner,Garth L. Nicolson +1 more
TL;DR: The least metastatic (parental) cell line was the most sensitive to activated macrophage-mediated cytolysis and cytostasis, while the most metastatic subline was the least sensitive in these assays.
Journal Article
Purification and some properties of a lung-derived growth factor that differentially stimulates the growth of tumor cells metastatic to the lung.
TL;DR: The results suggest that specific organ-derived growth factors are important in metastatic colonization and organ growth of particular malignant cells.
Journal Article
Heterogeneous response and clonal drift of sensitivities of metastatic 13762NF mammary adenocarcinoma clones to gamma-radiation in vitro.
TL;DR: It is revealed that considerable clonal heterogeneity exists within a tumor and its mA©tastases with respect to their response to y-radiation, and the inherent sensitivities may change with time, thereby altering radiation survival responses.
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Focal adhesion kinase regulates metastatic adhesion of carcinoma cells within liver sinusoids.
TL;DR: FAK appears to be involved in early events of integrin-mediated adhesion of circulating carcinoma cells under fluid flow in vitro and in vivo, and may take part in the establishment of definitive adhesive interactions that enable adherent tumor cells to resist fluid shear forces, resulting in an organ-specific formation of distant metastases.