G
Garth L. Nicolson
Researcher at University of Helsinki
Publications - 237
Citations - 23832
Garth L. Nicolson is an academic researcher from University of Helsinki. The author has contributed to research in topics: Cell culture & Membrane. The author has an hindex of 65, co-authored 228 publications receiving 23086 citations. Previous affiliations of Garth L. Nicolson include Salk Institute for Biological Studies & The New School.
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Journal ArticleDOI
Downregulation of urokinase-type plasminogen activator receptor (uPAR) induces caspase-mediated cell death in human glioblastoma cells.
Niranjan Yanamandra,Santhi D. Konduri,Sanjeeva Mohanam,Dzung H. Dinh,William C. Olivero,Meena Gujrati,Garth L. Nicolson,Mandri Obeyeseke,Jasti S. Rao +8 more
TL;DR: The results indicate that suppression of uPAR results in apoptosis and suggest that Caspase-9 dependent apoptosis plays an important role in SNB19 AS-uPAR-induced apoptosis.
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Incubation of human sperm with micelles made from glycerophospholipid mixtures increases sperm motility and resistance to oxidative stress.
Gonzalo Ferreira,Carlos Costa,Verónica Bassaizteguy,Marcelo Rodrigues dos Santos,Romina Cardozo,Jose Antonio Espinoza Montes,Robert Settineri,Garth L. Nicolson +7 more
TL;DR: Incubation of human sperm with glycerolphospholipids into the membranes of sperm improves sperm viability, motility, and resistance to oxidizing agents like H2O2, suggesting that human sperm might be useful to test innovative new treatments like MLR, since such treatments could improve fertility when it is adversely affected by increased oxidative stress.
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Lipid Replacement Therapy: a Functional Food Approach with New Formulations for Reducing Cellular Oxidative Damage, Cancer-Associated Fatigue and the Adverse Effects of Cancer Therapy
TL;DR: Cancer-associated fatigue and the chronic adverse effects of cancer therapy can be reduced by Lipid Replacement Therapy (LRT) using membrane phospholipid mixtures given as food supplements.
Journal Article
Cellular behavior of metastatic B16 melanoma in experimental blood-borne implantation and cerebral invasion. An electron microscopic study.
TL;DR: Using B16 melanoma variant subline B16-B14b, which was selected in vivo for enhanced brain surface colonization abilities in C57BL/6 mice, ultrastructural features of the cellular behavior of B 16 melanoma cells during the process of cerebral invasion were examined.
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Membrane structure and function: relevance of lipid and protein structures in cellular physiology, pathology and therapy.
TL;DR: This special issue of BBA Biomembranes aims to reflect the current status of this field, placing particular attention on the most recent advances in membrane structure, composition and dynamics, especially membrane lipids, as well as their modifications by therapeutic intervention.