G
Gary M. Bokoch
Researcher at University of California, San Diego
Publications - 3
Citations - 331
Gary M. Bokoch is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Phosphorylation cascade & Phosphorylation. The author has an hindex of 2, co-authored 3 publications receiving 326 citations.
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Journal ArticleDOI
p21-activated Kinase (PAK1) Is Phosphorylated and Activated by 3-phosphoinositide-dependent kinase-1 (PDK1)
Charles C. King,Elisabeth M. Gardiner,Frank Zenke,Benjamin P. Bohl,Alexandra C. Newton,Brian A. Hemmings,Gary M. Bokoch +6 more
TL;DR: Evidence is provided for a novel mechanism for PAK1 regulation and activation that is independent of phosphatidylinositol 3-kinase activity and based on the observation that these two proteins interact in vivo and that PDK1-phosphorylatedPAK1 has an increased activity toward substrate.
Journal ArticleDOI
Alpha 2-adrenergic receptor stimulation mobilizes intracellular Ca2+ in human erythroleukemia cells.
TL;DR: It is concluded that alpha 2-adrenergic receptors on human erythroleukemia cells couple to mobilization of intracellular Ca2+ via a (pertussis toxin-sensitive) G protein-mediated mechanism that is independent of inhibition of adenylate cyclase.
activation during chemotaxis Rac1 links leading edge and uropod events through Rho and myosin
Gary M. Bokoch,Michael Glogauer,Kersi Pestonjamasp,Carol Forster,Chunxiang Sun,Elisabeth M. Gardiner,Ben Bohl,Orion D. Weiner +7 more
TL;DR: It is demonstrated here that Rac1 (and not Rac2) is essential for Rho and myosin activation at the trailing edge to regulate uropod function, thereby promoting stable polarity in chemotaxing neutrophils.