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Alexandra C. Newton
Researcher at University of California, San Diego
Publications - 231
Citations - 24861
Alexandra C. Newton is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Protein kinase C & Phosphorylation. The author has an hindex of 73, co-authored 218 publications receiving 23469 citations. Previous affiliations of Alexandra C. Newton include Stanford University & University of California.
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Partitioning of lipid-modified monomeric GFPs into membrane microdomains of live cells.
TL;DR: Fluorescence resonance energy transfer measurements in living cells revealed that acyl but not prenyl modifications promote clustering in lipid rafts, and the nature of the lipid anchor on a protein is sufficient to determine submicroscopic localization within the plasma membrane.
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Protein Kinase C: Structure, Function, and Regulation
TL;DR: Multiple receptor pathways feeding into multiple lipid pathways have the common end result of activating protein kinase C by production of its second messenger, diacylglycerol.
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Protein Kinase C: Structural and Spatial Regulation by Phosphorylation, Cofactors, and Macromolecular Interactions
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Regulation of protein kinase C
TL;DR: Protein kinase C has been in the spotlight since the discovery two decades ago that it is activated by the lipid second messenger diacylglycerol, but the regulation and specific roles of its isozymes in defined cellular processes are still under intense investigation.
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PHLPP: A Phosphatase that Directly Dephosphorylates Akt, Promotes Apoptosis, and Suppresses Tumor Growth
TL;DR: PHLPP levels are markedly reduced in several colon cancer and glioblastoma cell lines that have elevated Akt phosphorylation, consistent with PHLPP terminating Akt signaling by directly dephosphorylating and inactivating Akt.