M
Marzia Malcangio
Researcher at Wolfson Centre for Age-Related Diseases
Publications - 133
Citations - 12444
Marzia Malcangio is an academic researcher from Wolfson Centre for Age-Related Diseases. The author has contributed to research in topics: Neuropathic pain & Nociception. The author has an hindex of 58, co-authored 123 publications receiving 11045 citations. Previous affiliations of Marzia Malcangio include Novartis & Queen Mary University of London.
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Book ChapterDOI
The role of glia in the spinal cord in neuropathic and inflammatory pain
TL;DR: Here microglia and astrocytes respond to the increased input from the periphery and change morphology, increase in number and release pro-nociceptive mediators such as ATP, cytokines and chemokines which contribute to central sensitization which is fundamental for the generation of allodynia, hyperalgesia and spontaneous pain.
Journal ArticleDOI
MAP kinase and pain
TL;DR: Central mechanisms of MAPKs, especially ERK, include regulating the activity of glutamate receptors and potassium channels and inducing gene transcription, which contribute to pain sensitization after tissue and nerve injury via distinct molecular and cellular mechanisms.
Journal ArticleDOI
Neurotrophin secretion: current facts and future prospects
TL;DR: Since BDNF has been proposed to play a critical role as an intercellular synaptic messenger in long-term potentiation (LTP) in the hippocampus, this article tries to reconcile this possible role of BDNF in LTP with the recently described features of synaptic BDNF secretion.
Journal ArticleDOI
Inhibition of spinal microglial cathepsin S for the reversal of neuropathic pain
Anna K. Clark,Ping K. Yip,John Grist,Clive Gentry,Amelia A. Staniland,Fabien Marchand,Maliheh Dehvari,Glen Wotherspoon,Janet Winter,Jakir Hussain Ullah,Stuart Bevan,Marzia Malcangio +11 more
TL;DR: It is suggested that under conditions of increased nociception, microglial CatS is responsible for the liberation of neuronal FKN, which stimulates p38 MAPK phosphorylation in microglia, thereby activating neurons via the release of pronociceptive mediators.
Journal ArticleDOI
Pain related behaviour in two models of osteoarthritis in the rat knee.
Janet Fernihough,Clive Gentry,Marzia Malcangio,Alyson Fox,John Rediske,Theodore C. Pellas,Bruce L. Kidd,Stuart Bevan,Janet Winter +8 more
TL;DR: An analysis of pain related behaviours in two models of OA in the rat: partial medial meniscectomy and iodoacetate injection provides a basis for studies on the mechanisms of pain in OA, and for development of novel therapeutic analgesics.