Gaurav Patki

TL;DR: It is suggested that social defeat stress alters ERK1/2, IL-6, GLO1, GSR1, CAMKIV, CREB, and BDNF levels in specific brain areas, leading to oxidative stress-induced anxiety-depression-like behaviors and as well as memory impairment in rats.

TL;DR: Exercise not only produces neuronal and mitochondrial protection, it also boosts nigrostriatal neurotrophic factor levels in the chronic parkinsonian mice with moderate neurodegeneration, indicating that modifying lifestyle with increased exercise activity would be a non‐pharmacological neuroprotective approach for averting neurodegenersative processes.

TL;DR: Moderate physical exercise ameliorates SPS-induced behavioral deficits in rats including anxiety and depression-like behaviors and memory impairment.

TL;DR: Protective role of GP is suggested in SPS-induced behavioral, cognitive, and biochemical impairments in rats, perhaps, epigenetic regulation of brain-derived neurotrophic factor enables GP-mediated prevention of S PS-induced deficits in rats.

TL;DR: Melatonin is not only mitochondrial protective but also moderately neuronal protective in the chronic Parkinson's mice, implying that long-term melatonin may potentially be effective for slowing down the progression of idiopathic Parkinson's disease and for reducing oxidative stress and respiratory chain inhibition in other mitochondrial disorders.