Gavin Sherlock

TL;DR: Annotare is a software tool that enables biologists to easily annotate their high-throughput experiments, biomaterials and data in a standards-compliant way that facilitates meaningful search and analysis.

TL;DR: This chapter describes the use of the primary tools for searching, browsing, retrieving, and analyzing data available for SMD, a DNA microarray research database that provides a large amount of data for public use.

TL;DR: The main focus of PortEco is to enable broad use of the growing number of high-throughput experiments available for E. coli, and to leverage community annotation through the EcoliWiki and GONUTS systems.

TL;DR: The proposed solution to the development of standards in systems-biology research is presented as a ‘top-down’ approach that ignores many existing and emerging standards and seems based on false assumptions about the research community and ignores the community it is intended to serve.

TL;DR: It is found that, despite differences in beneficial mutational mechanisms and fitness effects between two environments, early adaptive genetic diversity increases predictably, driven by the expansion of many single-mutant lineages, however, a crash in diversity follows, caused by highly-fit double-mutants fed from exponentially growing single- mutants.