G
Gavin Sherlock
Researcher at Stanford University
Publications - 177
Citations - 98574
Gavin Sherlock is an academic researcher from Stanford University. The author has contributed to research in topics: Gene & Population. The author has an hindex of 71, co-authored 164 publications receiving 88897 citations. Previous affiliations of Gavin Sherlock include University of Southern California & University of California, Berkeley.
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Journal ArticleDOI
The Valley-of-Death: reciprocal sign epistasis constrains adaptive trajectories in a constant, nutrient limiting environment.
Kami E. Chiotti,Daniel J. Kvitek,Karen H. Schmidt,Gregory Koniges,Katja Schwartz,Elizabeth A. Donckels,Frank Rosenzweig,Gavin Sherlock +7 more
TL;DR: This work sought to determine whether a ridge connected these peaks so that populations founded by one mutant could reach the peak created by the other, avoiding the low-fitness "Valley-of-Death" between them.
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Radiation-induced effects on gene expression: an in vivo study on breast cancer.
Åslaug Helland,Hilde Johnsen,Caroline Frøyland,Hege B.K. Landmark,Anna Barbro Sætersdal,Marit Muri Holmen,Turid Gjertsen,Jahn M. Nesland,William Ottestad,Stefanie S. Jeffrey,Lars Ottestad,Olag K. Rodningen,Gavin Sherlock,Anne Lise Børresen-Dale +13 more
TL;DR: Several genes involved in cell cycle regulation and DNA repair were found to be significantly induced by radiation treatment, and gene expression profiles observed seemed to be influenced by the TP53 mutation status.
Journal ArticleDOI
A guide to microarray experiments - an open letter to the scientific journals
Catherine A. Ball,Gavin Sherlock,Helen Parkinson,Philippe Rocca-Sera,Catherine Brooksbank,Helen C Causton,Duccio Cavalieri,Terry Gaasterland,Pascal Hingamp,Frank Holstege,M. Ringwald,Paul T. Spellman,Christian J Stoeckert,Jason E. Stewart,Ronald C. Taylor,Alvis Brazma,John Quackenbush +16 more
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APJ1 and GRE3 Homologs Work in Concert to Allow Growth in Xylose in a Natural Saccharomyces sensu stricto Hybrid Yeast
TL;DR: This work demonstrates that the power of sequencing combined with bulk segregant analysis can also be applied to a nongenetically tractable hybrid strain that contains a complex, polygenic trait, and identifies new avenues for metabolic engineering as well as for construction of nonginetically modified xylose-fermenting strains.
Journal ArticleDOI
Microarray Data Standards: An Open Letter
Catherine A. Ball,Alvis Brazma,Helen C. Causton,Steve Chervitz,Ron Edgar,Pascal Hingamp,John C. Matese,Helen Parkinson,John Quackenbush,Martin Ringwald,Susanna-Assunta Sansone,Gavin Sherlock,Paul T. Spellman,Christian J. Stoeckert,Yoshio Tateno,Ronald C. Taylor,Joseph White,Neil Winegarden +17 more
TL;DR: The members of the MGED Society propose the following as a new paradigm for the publication of microarray-based studies: submission requirements should be applied consistently and that journals recognize ArrayExpress and Gene Expression Omnibus as acceptable public repositories.