G
Gavin Sherlock
Researcher at Stanford University
Publications - 177
Citations - 98574
Gavin Sherlock is an academic researcher from Stanford University. The author has contributed to research in topics: Gene & Population. The author has an hindex of 71, co-authored 164 publications receiving 88897 citations. Previous affiliations of Gavin Sherlock include University of Southern California & University of California, Berkeley.
Papers
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Journal ArticleDOI
Reciprocal Sign Epistasis between Frequently Experimentally Evolved Adaptive Mutations Causes a Rugged Fitness Landscape
Daniel J. Kvitek,Gavin Sherlock +1 more
TL;DR: Evidence of a rugged molecular fitness landscape arising during an evolution experiment in an asexual population of Saccharomyces cerevisiae is provided and epistasis plays a key role during adaptation and that inter-genic interactions can act as barriers between adaptive solutions are shown.
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The Candida Genome Database (CGD): incorporation of Assembly 22, systematic identifiers and visualization of high throughput sequencing data
Marek S. Skrzypek,Jonathan Binkley,Gail Binkley,Stuart R. Miyasato,Matt Simison,Gavin Sherlock +5 more
TL;DR: The incorporation into CGD of Assembly 22, the first chromosome-level, phased diploid assembly of the C. albicans genome, is reported, coupled with improvements that have been made to the assembly using additional available sequence data.
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The Aspergillus Genome Database: multispecies curation and incorporation of RNA-Seq data to improve structural gene annotations
Gustavo C. Cerqueira,Martha B. Arnaud,Diane O. Inglis,Marek S. Skrzypek,Gail Binkley,Matt Simison,Stuart R. Miyasato,Jonathan Binkley,Joshua Orvis,Prachi Shah,Farrell Wymore,Gavin Sherlock,Jennifer R. Wortman +12 more
TL;DR: This update reports substantive structural annotation improvements for A. nidulans, A. oryzae and A. fumigatus genomes based on recently available RNA-Seq data.
Imputing Missing Data for Gene Expression Arrays
Trevor Hastie,Robert Tibshirani,Gavin Sherlock,Michael B. Eisen,Patrick O. Brown,David Botstein +5 more
TL;DR: The singular value decomposition offers an interesting and stable method for imputation of missing values in gene expression arrays by regressing its non-missing entries on the eigen-genes and using the regression function to predict the expression values at the missing locations.
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Comprehensive annotation of secondary metabolite biosynthetic genes and gene clusters of Aspergillus nidulans, A. fumigatus, A. niger and A. oryzae
Diane O. Inglis,Jonathan Binkley,Marek S. Skrzypek,Martha B. Arnaud,Gustavo C. Cerqueira,Prachi Shah,Farrell Wymore,Jennifer R. Wortman,Gavin Sherlock +8 more
TL;DR: This set of 266 manually curated secondary metabolite gene clusters will facilitate the investigation of novel Aspergillus secondary metabolites and help predict roles in secondary metabolism for genes lacking experimental characterization.