G
Gayane Manukyan
Researcher at Palacký University, Olomouc
Publications - 39
Citations - 781
Gayane Manukyan is an academic researcher from Palacký University, Olomouc. The author has contributed to research in topics: Familial Mediterranean fever & Immune system. The author has an hindex of 11, co-authored 36 publications receiving 639 citations. Previous affiliations of Gayane Manukyan include Armenian National Academy of Sciences & Russian-Armenian (Slavonic) University.
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Journal ArticleDOI
Predominant role of host genetics in controlling the composition of gut microbiota
Zaruhi Khachatryan,Zhanna A. Ktsoyan,Gayane Manukyan,Denise Kelly,Karine A. Ghazaryan,Rustam Aminov +5 more
TL;DR: This is the first report that clearly establishes the link between the host genotype and the corresponding shifts in the gut microbiota, which suggests that the host genetics is a key factor in host-microbe interaction determining a specific profile of commensal microbiota in the human gut.
Journal ArticleDOI
Update on Pyrin Functions and Mechanisms of Familial Mediterranean Fever
Gayane Manukyan,Rustam Aminov +1 more
TL;DR: Based on these functions, the FMF-associated versions of pyrin confer a heightened sensitivity to a variety of intracellular danger signals and postpone the resolution of innate immune responses.
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Cytokine profile of Armenian patients with Familial Mediterranean fever.
Gayane Manukyan,Karine A. Ghazaryan,Zh. A. Ktsoyan,M. Tatyan,Zaruhi Khachatryan,Gagik Hakobyan,V.A. Mkrtchyan,Denise Kelly,Alistair G.P. Coutts,Rustam Aminov +9 more
TL;DR: Inflammation in FMF involves Treg and Th17 lineages and the levels of IL-6,IL-10, IL-17, TGF-beta, CRP, and sIL-2R were significantly different from the norm and FMF remission.
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Gender-related differences observed among immune cells in synovial fluid in knee osteoarthritis.
Eva Kriegova,Gayane Manukyan,Zuzana Mikulková,G. Gabcova,Milos Kudelka,Petr Gajdoš,Jiri Gallo +6 more
TL;DR: This first study on the cellular complexity of SFs in KOA showed marked differences between male and female patients, which give a rational starting point for patient stratification according to their phenotypes, as is required for phenotype-specific treatment strategies.
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Elevated systemic antibodies towards commensal gut microbiota in autoinflammatory condition.
Gayane Manukyan,Karine A. Ghazaryan,Zhanna A. Ktsoyan,Zaruhi Khachatryan,Karine A. Arakelova,Denise Kelly,George Grant,Rustam Aminov +7 more
TL;DR: Familial Mediterranean fever is characterized by the increased systemic reactivity against commensal gut microbiota, probably the consequence of hypersensitivity of the inflammasome in FMF that triggers the inflammation and contributes to the excessive translocation of bacteria and bacterial antigens through the gut barrier.