Geary W. Olsen

TL;DR: Humans appear to have a long half-life of serum elimination of PFOS, PFHS, and PFOA, which may be due, in part, to a saturable renal resorption process.

TL;DR: The hepatocellular tumors observed in rats are likely to have been the result of the activation of the peroxisome proliferator activated receptor α (PPARα), and the proposed mechanism for Leydig-cell tumor formation is of questionable relevance to humans.

TL;DR: Comparison of serum PFOS concentrations associated with no adverse effect in this study to those reported in human blood samples indicated an adequate margin of safety.

TL;DR: In this investigation, a total of 645 adult donor serum samples from six American Red Cross blood collection centers were analyzed for PFOS and six other fluorochemicals using HPLC-electrospray tandem mass spectrometry.

TL;DR: Serum concentrations of PFOS and perfluorooctanoate (PFOA, C7F15CO2−, used as a fluoropolymer emulsifier) were measured via mass spectrometry methods and there were no substantial changes in hematological, lipid, hepatic, thyroid, or urinary parameters consistent with the known toxicological effects ofPFOS or PFOA in cross-sectional or longitudinal analyses of the workers’ measured serum fluorochemical concentrations.