J
John L. Butenhoff
Researcher at University of Rochester Medical Center
Publications - 78
Citations - 10117
John L. Butenhoff is an academic researcher from University of Rochester Medical Center. The author has contributed to research in topics: Population & Hormone. The author has an hindex of 47, co-authored 78 publications receiving 8939 citations.
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Journal ArticleDOI
Half-life of serum elimination of perfluorooctanesulfonate,perfluorohexanesulfonate, and perfluorooctanoate in retired fluorochemical production workers.
Geary W. Olsen,Jean M. Burris,David J. Ehresman,John W. Froehlich,Andrew M. Seacat,John L. Butenhoff,Larry R. Zobel +6 more
TL;DR: Humans appear to have a long half-life of serum elimination of PFOS, PFHS, and PFOA, which may be due, in part, to a saturable renal resorption process.
Journal ArticleDOI
The toxicology of perfluorooctanoate.
Gerald L. Kennedy,John L. Butenhoff,Geary W. Olsen,John C. O'Connor,Andrew M. Seacat,Roger Perkins,Lisa B. Biegel,Sandra R. Murphy,David G. Farrar +8 more
TL;DR: The hepatocellular tumors observed in rats are likely to have been the result of the activation of the peroxisome proliferator activated receptor α (PPARα), and the proposed mechanism for Leydig-cell tumor formation is of questionable relevance to humans.
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Subchronic toxicity studies on perfluorooctanesulfonate potassium salt in cynomolgus monkeys.
Andrew M. Seacat,Peter J. Thomford,Kris J Hansen,Geary W. Olsen,Marvin T. Case,John L. Butenhoff +5 more
TL;DR: Comparison of serum PFOS concentrations associated with no adverse effect in this study to those reported in human blood samples indicated an adequate margin of safety.
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Sub-chronic dietary toxicity of potassium perfluorooctanesulfonate in rats
Andrew M. Seacat,Peter J. Thomford,Kris J Hansen,Lisa A Clemen,Sandra R Eldridge,Cliff Elcombe,John L. Butenhoff +6 more
TL;DR: It is suggested that lowering of serum total cholesterol may not be the earliest clinically-measurable response to treatment in the rat and it is confirmed that serum and liver PFOS concentrations on repeated dosing are proportional to dose and cumulative dose.
Journal ArticleDOI
Interactions of flurochemicals with rat liver fatty acid-binding protein
TL;DR: In vitro data presented in this study support the hypothesis that these fluorochemicals may interfere with the binding of fatty acids or other endogenous ligands to L-FABP and provide evidence to support the hypotheses that displacement of endogenous ligand from L- FABP may contribute to toxicity in rodents fed these fluorochemicalicals.