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Peter J. Thomford
Researcher at Covance
Publications - 8
Citations - 1623
Peter J. Thomford is an academic researcher from Covance. The author has contributed to research in topics: Toxicity & Excretion. The author has an hindex of 7, co-authored 8 publications receiving 1540 citations.
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Journal ArticleDOI
Subchronic toxicity studies on perfluorooctanesulfonate potassium salt in cynomolgus monkeys.
Andrew M. Seacat,Peter J. Thomford,Kris J Hansen,Geary W. Olsen,Marvin T. Case,John L. Butenhoff +5 more
TL;DR: Comparison of serum PFOS concentrations associated with no adverse effect in this study to those reported in human blood samples indicated an adequate margin of safety.
Journal ArticleDOI
Sub-chronic dietary toxicity of potassium perfluorooctanesulfonate in rats
Andrew M. Seacat,Peter J. Thomford,Kris J Hansen,Lisa A Clemen,Sandra R Eldridge,Cliff Elcombe,John L. Butenhoff +6 more
TL;DR: It is suggested that lowering of serum total cholesterol may not be the earliest clinically-measurable response to treatment in the rat and it is confirmed that serum and liver PFOS concentrations on repeated dosing are proportional to dose and cumulative dose.
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Toxicity of ammonium perfluorooctanoate in male cynomolgus monkeys after oral dosing for 6 months.
John L. Butenhoff,Giovanni Costa,Cliff Elcombe,David G. Farrar,Kristin Hansen,Hiroyuki Iwai,Reinhard Jung,Gerald L. Kennedy,Paul H. Lieder,Geary W. Olsen,Peter J. Thomford +10 more
TL;DR: There were no APFO-related macroscopic or microscopic changes, changes in clinical chemistry, hormones, or urinalysis, or hematological effects, and effects that have been associated with the development of pancreatic and testicular toxicity in rats were not observed in this study.
Journal ArticleDOI
Preclinical Safety Evaluation of rhuMAbVEGF, an Antiangiogenic Humanized Monoclonal Antibody
Anne M. Ryan,Dorothy Bates Eppler,Kelly E. Hagler,Richard H. Bruner,Peter J. Thomford,Robert L. Hall,George M. Shopp,C. A. O'Neill +7 more
TL;DR: Findings indicate that VEGF is required for longitudinal bone growth and corpora lutea formation and that rhuMAbVEGF can reversibly inhibit physiologic neovascularization at these sites.
Journal ArticleDOI
Pharmacokinetics of Perfluorooctanoate in Cynomolgus Monkeys
John L. Butenhoff,Gerald L. Kennedy,Paul M. Hinderliter,Paul H. Lieder,Reinhard Jung,Kris J Hansen,Gregory S. Gorman,Patricia E. Noker,Peter J. Thomford +8 more
TL;DR: The pharmacokinetics of perfluorooctanoate (PFOA) in cynomolgus monkeys were studied in a six-month oral capsule dosing study of APFO and in a single-dose iv study, and the elimination half-life is approximately 14-42 days, and urine is the primary route of excretion.