Geetanjali Chawla

TL;DR: It is shown that the splicing of a large group of exons is reprogrammed during neuronal development by a switch in expression between two highly similar polypyrimidine tract-binding proteins, PTB and nPTB (neural PTB).

TL;DR: It is shown here that the repression of nPTB expression during myoblast differentiation results from its targeting by the muscle-restricted microRNA miR-133, which directly down-regulates a key splicing factor during muscle development and establishes a role for microRNAs in the control of a developmentally dynamic splicing program.

TL;DR: In this paper, the authors found that postsynaptic density protein 95 (PSD-95) was controlled post-transcriptionally during neural development by two PTB proteins whose sequential downregulation is necessary for synapse maturation.

TL;DR: Using RNA interference knockdown of Sam68 expression and splicing-sensitive microarrays, a set of alternative exons whose splicing depends on Sam68 are identified and detailed analysis of one newly identified target exon in epsilon sarcoglycan (Sgce) showed that both RNA elements distributed across the adjacent introns and the RNA binding activity of Sam 68 are necessary to repress the Sgce exon.

TL;DR: Findings indicate that steroid hormone-coupled control of let-7-C microRNAs is part of an ancestral pathway controlling the transition from larval-to-reproductive animal forms.