D
Douglas L. Black
Researcher at University of California, Los Angeles
Publications - 98
Citations - 15258
Douglas L. Black is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: RNA splicing & Alternative splicing. The author has an hindex of 57, co-authored 91 publications receiving 13752 citations. Previous affiliations of Douglas L. Black include University of California, Berkeley & Howard Hughes Medical Institute.
Papers
More filters
Journal ArticleDOI
Mechanisms of Alternative Pre-Messenger RNA Splicing
TL;DR: This review describes what is currently known of the molecular mechanisms that control changes in splice site choice and starts with the best-characterized systems from the Drosophila sex determination pathway, and then describes the regulators of other systems about whose mechanisms there is some data.
Journal ArticleDOI
Protein diversity from alternative splicing: a challenge for bioinformatics and post-genome biology.
TL;DR: In addition to improving algorithms for predicting spliced segments within genomic sequence, bioinformatics approaches will be important in predicting alternative splicing patterns from genomic sequence to give insight into the mechanisms of alternativesplicing and help experimentalists make sense of their complex biochemical systems.
Journal ArticleDOI
A post-transcriptional regulatory switch in polypyrimidine tract-binding proteins reprograms alternative splicing in developing neurons
Paul L. Boutz,Peter Stoilov,Qin Li,Chia-Ho Lin,Geetanjali Chawla,Kristin Ostrow,Lily Shiue,Manuel Ares,Douglas L. Black +8 more
TL;DR: It is shown that the splicing of a large group of exons is reprogrammed during neuronal development by a switch in expression between two highly similar polypyrimidine tract-binding proteins, PTB and nPTB (neural PTB).
Journal ArticleDOI
Genome-wide Analysis of PTB-RNA Interactions Reveals a Strategy Used by the General Splicing Repressor to Modulate Exon Inclusion or Skipping
Yuanchao Xue,Yu Zhou,Yu Zhou,Tongbin Wu,Tuo Zhu,Xiong Ji,Young-Soo Kwon,Chao Zhang,Gene W. Yeo,Douglas L. Black,Hui Sun,Xiang-Dong Fu,Xiang-Dong Fu,Yi Zhang +13 more
TL;DR: A mechanism for PTB to modulate splice site competition to produce opposite functional consequences is suggested, which may be generally applicable to RNA-binding splicing factors to positively or negatively regulate alternative splicing in mammalian cells.
Journal ArticleDOI
Transcript Dynamics of Proinflammatory Genes Revealed by Sequence Analysis of Subcellular RNA Fractions
Dev M. Bhatt,Amy Pandya-Jones,Ann Jay Tong,Iros Barozzi,Michelle M. Lissner,Gioacchino Natoli,Douglas L. Black,Stephen T. Smale +7 more
TL;DR: The results provide a high-resolution view of the relationship between defined promoter and chromatin properties and the temporal regulation of diverse classes of coexpressed genes and a striking accumulation of full-length yet incompletely spliced transcripts in the chromatin fraction.