G
Geoff Holder
Researcher at Selly Oak Hospital
Publications - 11
Citations - 797
Geoff Holder is an academic researcher from Selly Oak Hospital. The author has contributed to research in topics: Hydrocortisone & Cortisone. The author has an hindex of 8, co-authored 11 publications receiving 767 citations.
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Journal ArticleDOI
Growth Hormone and Pituitary Radiotherapy, But Not Serum Insulin-Like Growth Factor-I Concentrations, Predict Excess Mortality in Patients with Acromegaly
TL;DR: It is suggested that reduction of GH levels to less than 2 micro g/liter is beneficial in terms of improving long-term outcome and the sole use of IGF-I as a marker for effective treatment of acromegaly is not justified by this data.
Journal ArticleDOI
The long-term predictive accuracy of the short synacthen (corticotropin) stimulation test for assessment of the hypothalamic-pituitary-adrenal axis.
TL;DR: The high-dose short Synacthen (corticotropin) test is safe for the purpose of excluding clinically significant secondary adrenal insufficiency and is indicated as the first line of investigation for this purpose.
The long-term predictive accuracy of the short synacthen (corticotropin) stimulation test for assessment of the hypothalamic-pituitary-adrenal axis
TL;DR: In this article, the authors evaluated the long-term safety of the SST and concluded that it is safe for the purpose of excluding clinically significant secondary adrenal insufficiency and is indicated as the first line of investigation for this purpose.
CLINICAL CASE SEMINAR Absence of Cushingoid Phenotype in a Patient with Cushing's Disease due to Defective Cortisone to Cortisol Conversion
Jeremy W. Tomlinson,Nicole Draper,Joanna Mackie,Alan P. Johnson,Geoff Holder,Peter J. Wood,Paul M. Stewart +6 more
TL;DR: A case of Cushing's disease that failed to present with a classical phenotype is described, and it is postulate that this is due to a partial defect of 11beta-HSD1 activity, the defect in cortisone to cortisol conversion increasing cortisol clearance and thus protecting the patient from the effects of cortisol excess.
Journal ArticleDOI
Absence of Cushingoid phenotype in a patient with Cushing's disease due to defective cortisone to cortisol conversion.
Jeremy W. Tomlinson,Nicole Draper,Joanna Mackie,Alan P. Johnson,Geoff Holder,Peter J. Wood,Paul M. Stewart +6 more
TL;DR: The case of a 20-year-old student with pituitary-dependent Cushing's syndrome who was spared this classical phenotype because of a defect in the peripheral conversion of cortisone to cortisol was reported in this article.