Institution
Selly Oak Hospital
Healthcare•Birmingham, United Kingdom•
About: Selly Oak Hospital is a healthcare organization based out in Birmingham, United Kingdom. It is known for research contribution in the topics: Poison control & Population. The organization has 930 authors who have published 797 publications receiving 23254 citations.
Papers published on a yearly basis
Papers
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TL;DR: These findings represent the first germline loss-of-function mutations in PPARγ and provide compelling genetic evidence that this receptor is important in the control of insulin sensitivity, glucose homeostasis and blood pressure in man.
Abstract: Thiazolidinediones are a new class of antidiabetic agent that improve insulin sensitivity and reduce plasma glucose and blood pressure in subjects with type 2 diabetes. Although these agents can bind and activate an orphan nuclear receptor, peroxisome proliferator-activated receptor gamma (PPARgamma), there is no direct evidence to conclusively implicate this receptor in the regulation of mammalian glucose homeostasis. Here we report two different heterozygous mutations in the ligand-binding domain of PPARgamma in three subjects with severe insulin resistance. In the PPARgamma crystal structure, the mutations destabilize helix 12 which mediates transactivation. Consistent with this, both receptor mutants are markedly transcriptionally impaired and, moreover, are able to inhibit the action of coexpressed wild-type PPARgamma in a dominant negative manner. In addition to insulin resistance, all three subjects developed type 2 diabetes mellitus and hypertension at an unusually early age. Our findings represent the first germline loss-of-function mutations in PPARgamma and provide compelling genetic evidence that this receptor is important in the control of insulin sensitivity, glucose homeostasis and blood pressure in man.
1,320 citations
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TL;DR: The cause of hyperglycaemia changes the response to hypoglycaemic drugs; HNF-1alpha diabetes has marked sulphonylurea sensitivity; this pharmacogenetic effect is consistent with models of HNF -1alpha deficiency, which show that the beta-cell defect is upstream of the sulphonyLurea receptor.
529 citations
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TL;DR: It is suggested that assessment of left-ventricular function in patients with suspected heart failure could lead to more effective diagnosis and treatment of this disorder.
481 citations
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TL;DR: The majority of treated in-hospital cardiac arrests are potentially avoidable, and multiple system failures include delays and errors in diagnosis, inadequate interpretation of investigations, incomplete treatment, inexperienced doctors and management in inappropriate clinical areas.
401 citations
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TL;DR: Risk factors for cardiac arrest have been identified, quantified and formulated into a table of activation criteria to help predict and avert cardiac arrest by alerting a clinical response.
327 citations
Authors
Showing all 930 results
Name | H-index | Papers | Citations |
---|---|---|---|
Paul M. Stewart | 99 | 440 | 37169 |
C. N. Hales | 73 | 178 | 28197 |
Malcolm W.R. Reed | 70 | 310 | 21129 |
Raashid Luqmani | 61 | 341 | 25045 |
Paul G. Winyard | 59 | 222 | 12543 |
Helen R. Griffiths | 50 | 215 | 8083 |
Denis O'Mahony | 49 | 215 | 15708 |
Paul Bennett | 47 | 263 | 7435 |
Desmond O'Neill | 44 | 450 | 8696 |
Fidelma Dunne | 43 | 207 | 6543 |
Nick Taub | 41 | 102 | 9102 |
Wilfred C. G. Peh | 41 | 348 | 5524 |
Fotios Drenos | 40 | 110 | 7662 |
Martin Grootveld | 40 | 172 | 6544 |
Martin R. Miller | 37 | 171 | 26685 |