G
Geoff P. O’Donoghue
Researcher at University of California, Berkeley
Publications - 13
Citations - 466
Geoff P. O’Donoghue is an academic researcher from University of California, Berkeley. The author has contributed to research in topics: T-cell receptor & T cell. The author has an hindex of 8, co-authored 13 publications receiving 394 citations. Previous affiliations of Geoff P. O’Donoghue include Williams College & Lawrence Berkeley National Laboratory.
Papers
More filters
Journal ArticleDOI
Direct single molecule measurement of TCR triggering by agonist pMHC in living primary T cells
Geoff P. O’Donoghue,Geoff P. O’Donoghue,Rafal M. Pielak,Rafal M. Pielak,Alexander A. Smoligovets,Alexander A. Smoligovets,Jenny J. Lin,Jenny J. Lin,Jay T. Groves,Jay T. Groves +9 more
TL;DR: Single molecule measurements of the pM HC:TCR:ZAP70 complex indicate that TCR triggering is stoichiometric with agonist pMHC in a 1:1 ratio, which means any signal amplification must occur downstream of T CR triggering.
Journal ArticleDOI
Investigating Cell Surface Galectin-Mediated Cross-Linking on Glycoengineered Cells
TL;DR: This platform offers a new approach to exploring the “galectin lattice” hypothesis and to defining galectin ligand specificity in a physiologically relevant context.
Journal ArticleDOI
Supported Membranes Embedded with Fixed Arrays of Gold Nanoparticles
Theobald Lohmüller,Sara B. Triffo,Geoff P. O’Donoghue,Qian Xu,Michael P. Coyle,Jay T. Groves,Jay T. Groves +6 more
TL;DR: A supported membrane platform consisting of a fluid lipid bilayer membrane embedded with a fixed array of gold nanoparticles, providing a hybrid interface consisting of mobile and immobile components with controlled geometry is presented.
Journal ArticleDOI
Early T cell receptor signals globally modulate ligand:receptor affinities during antigen discrimination.
Rafal M. Pielak,Geoff P. O’Donoghue,Jenny J. Lin,Katherine N. Alfieri,Nicole C. Fay,Shalini T. Low-Nam,Jay T. Groves +6 more
TL;DR: Individual ligand:receptor binding and unbinding events in space and time are monitored by single-molecule imaging in live primary T cells for a range of different pMHC ligands and surface densities to reveal an active feedback mechanism that globally modulates the probability of pM HC:TCR binding throughout the cell–cell interface, without affecting the unbinding rate.
Journal ArticleDOI
Interrogating cellular perception and decision making with optogenetic tools
TL;DR: The ways by which optogenetic tools and techniques are being used to query cellular signaling and function are examined in this Viewpoint article.