G
Geoffrey G. Hesketh
Researcher at Lunenfeld-Tanenbaum Research Institute
Publications - 43
Citations - 2241
Geoffrey G. Hesketh is an academic researcher from Lunenfeld-Tanenbaum Research Institute. The author has contributed to research in topics: Endosome & GTPase. The author has an hindex of 24, co-authored 43 publications receiving 1710 citations. Previous affiliations of Geoffrey G. Hesketh include Johns Hopkins University & Johns Hopkins University School of Medicine.
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Journal ArticleDOI
A proximity-dependent biotinylation map of a human cell.
Christopher D. Go,Christopher D. Go,James D.R. Knight,Archita Rajasekharan,Bhavisha Rathod,Geoffrey G. Hesketh,Kento T. Abe,Kento T. Abe,Ji-Young Youn,Ji-Young Youn,Payman Samavarchi-Tehrani,Hui Zhang,Lucie Y. Zhu,Evelyn Popiel,Jean-Philippe Lambert,Jean-Philippe Lambert,Etienne Coyaud,Etienne Coyaud,Sally W.T. Cheung,Dushyandi Rajendran,Cassandra J. Wong,Hana Antonicka,Laurence Pelletier,Laurence Pelletier,Alexander F. Palazzo,Eric A. Shoubridge,Brian Raught,Brian Raught,Anne-Claude Gingras,Anne-Claude Gingras +29 more
TL;DR: In this article, a proximity-dependent biotinylation technique was used to define the location of more than 4,000 proteins in a human cell and almost 36,000 proximal interactions between proteins, including those at the interface of the mitochondria and ER.
Journal ArticleDOI
Dynamic changes in conduction velocity and gap junction properties during development of pacing-induced heart failure.
Fadi G. Akar,Robert D. Nass,Samuel Hahn,Eugenio Cingolani,Manish A. Shah,Geoffrey G. Hesketh,Deborah DiSilvestre,Richard S. Tunin,David A. Kass,Gordon F. Tomaselli +9 more
TL;DR: High-resolution optical mapping in arterially perfused myocardial preparations from dogs subjected to 0, 3, 7, 14, and 21 days of rapid pacing reveals a novel paradigm of remodeling based on the timing of conduction abnormalities relative to changes in Cx43 isoforms and mechanical dysfunction.
Journal ArticleDOI
Electrophysiological Consequences of Dyssynchronous Heart Failure and Its Restoration by Resynchronization Therapy
Takeshi Aiba,Geoffrey G. Hesketh,Andreas S. Barth,Ting Liu,Samantapudi Daya,Khalid Chakir,Veronica L Dimaano,Theodore P. Abraham,Brian O'Rourke,Fadi G. Akar,David A. Kass,Gordon F. Tomaselli +11 more
TL;DR: CRT partially restores DHF-induced ion channel remodeling and abnormal Ca2+ homeostasis and attenuates the regional heterogeneity of action potential duration.
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Cyclic GMP/PKG-Dependent Inhibition of TRPC6 Channel Activity and Expression Negatively Regulates Cardiomyocyte NFAT Activation: Novel Mechanism of Cardiac Stress Modulation by PDE5 Inhibition
Norimichi Koitabashi,Takeshi Aiba,Geoffrey G. Hesketh,Janelle Rowell,Manling Zhang,Eiki Takimoto,Gordon F. Tomaselli,David A. Kass +7 more
TL;DR: The hypothesis that PKG blocks Cn/NFAT activation by modifying and thus inhibiting TRPC6 current to break the positive feedback loop involving NFAT and NFAT-dependent TRPC 6 upregulation is tested.
Journal ArticleDOI
Ultrastructure and Regulation of Lateralized Connexin43 in the Failing Heart
Geoffrey G. Hesketh,Manish H. Shah,Manish H. Shah,Victoria L. Halperin,Carol A. Cooke,Fadi G. Akar,Timothy E. Yen,David A. Kass,Carolyn E. Machamer,Jennifer E. Van Eyk,Gordon F. Tomaselli +10 more
TL;DR: The data demonstrate a previously unrecognized pathway of gap junction internalization and degradation in the heart and identify a cellular pathway with potential therapeutic implications.