J
James D.R. Knight
Researcher at Lunenfeld-Tanenbaum Research Institute
Publications - 39
Citations - 4189
James D.R. Knight is an academic researcher from Lunenfeld-Tanenbaum Research Institute. The author has contributed to research in topics: Interactome & Phosphorylation. The author has an hindex of 27, co-authored 36 publications receiving 3125 citations. Previous affiliations of James D.R. Knight include Mount Sinai Hospital & University of Ottawa.
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Journal ArticleDOI
The genome sequence of Atlantic cod reveals a unique immune system
Bastiaan Star,Alexander J. Nederbragt,Sissel Jentoft,Unni Grimholt,Martin Malmstrøm,Tone F. Gregers,Trine B. Rounge,Jonas Paulsen,Jonas Paulsen,Monica Hongrø Solbakken,Animesh Sharma,Ola F. Wetten,Ola F. Wetten,Anders Lanzén,Roger Winer,James D.R. Knight,Jan-Hinnerk Vogel,Bronwen Aken,Øivind Andersen,Karin Lagesen,Ave Tooming-Klunderud,Rolf B. Edvardsen,Kirubakaran G. Tina,Kirubakaran G. Tina,Mari Espelund,Chirag Nepal,Christopher Previti,Bård Ove Karlsen,Truls Moum,Morten Skage,Paul R. Berg,Tor Gjøen,Heiner Kuhl,Jim Thorsen,Ketil Malde,Richard Reinhardt,Lei Du,Steinar Johansen,Steinar Johansen,Steve Searle,Sigbjørn Lien,Frank Nilsen,Inge Jonassen,Stig W. Omholt,Stig W. Omholt,Nils Christian Stenseth,Kjetill S. Jakobsen +46 more
TL;DR: The genome sequence of Atlantic cod is presented, showing evidence for complex thermal adaptations in its haemoglobin gene cluster and an unusual immune architecture compared to other sequenced vertebrates.
Journal ArticleDOI
High-Density Proximity Mapping Reveals the Subcellular Organization of mRNA-Associated Granules and Bodies
Ji-Young Youn,Wade H. Dunham,Seo Jung Hong,James D.R. Knight,Mikhail Bashkurov,Ginny I. Chen,Ginny I. Chen,Halil Bagci,Bhavisha Rathod,Graham MacLeod,Simon W. M. Eng,Stephane Angers,Quaid Morris,Marc R. Fabian,Marc R. Fabian,Jean-François Côté,Anne-Claude Gingras,Anne-Claude Gingras +17 more
TL;DR: Systematic in-vivo proximity-dependent biotinylation analysis of 119 human proteins associated with different aspects of mRNA biology uncovers 7424 unique proximity interactions with 1,792 proteins, which enables the definition of 144 core components of SGs and PBs.
Journal ArticleDOI
A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface.
Gagan D. Gupta,Etienne Coyaud,João Gonçalves,Bahareh A. Mojarad,Yi Liu,Yi Liu,Qianzhu Wu,Qianzhu Wu,Ladan Gheiratmand,David Comartin,David Comartin,Johnny M. Tkach,Sally W.T. Cheung,Mikhail Bashkurov,Monica Hasegan,James D.R. Knight,Zhen-Yuan Lin,Markus Schueler,Friedhelm Hildebrandt,Friedhelm Hildebrandt,Jason Moffat,Anne-Claude Gingras,Anne-Claude Gingras,Brian Raught,Brian Raught,Laurence Pelletier,Laurence Pelletier +26 more
TL;DR: Systematic profiling of proximity interactions combined with functional analysis provides a rich resource for better understanding human centrosome and cilia biology and may be applied to other complex biological structures or pathways.
Journal ArticleDOI
Protein Interaction Network of the Mammalian Hippo Pathway Reveals Mechanisms of Kinase-Phosphatase Interactions
Amber L. Couzens,James D.R. Knight,Michelle J. Kean,Michelle J. Kean,Guo Ci Teo,Alexander Weiss,Wade H. Dunham,Zhen-Yuan Lin,Richard D. Bagshaw,Frank Sicheri,Frank Sicheri,Tony Pawson,Tony Pawson,Jeffrey L. Wrana,Jeffrey L. Wrana,Hyungwon Choi,Anne-Claude Gingras,Anne-Claude Gingras +17 more
TL;DR: Results indicated that changes in phosphorylation orchestrate interactions between kinases and phosphatases in Hippo signaling, providing a putative mechanism for pathway regulation.
Journal ArticleDOI
Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes.
Jean-Philippe Lambert,Monika Tucholska,Christopher D. Go,James D.R. Knight,Anne-Claude Gingras,Anne-Claude Gingras +5 more
TL;DR: This manuscript describes the application of BioID, a proximity biotinylation approach, to chromatin-associated proteins, namely core histones and members of the mediator complex, and shows that the approaches were complementary, allowing for purification of different interaction partners.