G
Georg F. Weber
Researcher at University of Cincinnati Academic Health Center
Publications - 139
Citations - 9453
Georg F. Weber is an academic researcher from University of Cincinnati Academic Health Center. The author has contributed to research in topics: Osteopontin & Cancer. The author has an hindex of 40, co-authored 129 publications receiving 8551 citations. Previous affiliations of Georg F. Weber include University of Cincinnati & Ventana Medical Systems.
Papers
More filters
Journal ArticleDOI
Eta-1 (Osteopontin): An Early Component of Type-1 (Cell-Mediated) Immunity
Samy Ashkar,Georg F. Weber,Vassiliki Panoutsakopoulou,Marie E. Sanchirico,Marianne Jansson,Samer Zawaideh,Susan R. Rittling,David T. Denhardt,Melvin J. Glimcher,Harvey Cantor +9 more
TL;DR: Findings identify Eta-1 as a key cytokine that sets the stage for efficient type-1 immune responses through differential regulation of macrophage IL-12 and IL-10 cytokine expression.
Journal ArticleDOI
Receptor-Ligand Interaction Between CD44 and Osteopontin (Eta-1)
TL;DR: The cytokine osteopontin (Eta-1), which regulates similar cellular functions, was found to be a protein ligand of CD44, and may be exploited by tumor cells to promote metastasis formation.
Journal ArticleDOI
Local proliferation dominates lesional macrophage accumulation in atherosclerosis
Clinton S. Robbins,Ingo Hilgendorf,Georg F. Weber,Igor Theurl,Yoshiko Iwamoto,Jose-Luiz Figueiredo,Jose-Luiz Figueiredo,Rostic Gorbatov,Galina K. Sukhova,Louisa M.S. Gerhardt,David J. Smyth,Caleb C. J. Zavitz,Eric A. Shikatani,Eric A. Shikatani,Michael Parsons,Nico van Rooijen,Herbert Y. Lin,Mansoor Husain,Mansoor Husain,Peter Libby,Matthias Nahrendorf,Ralph Weissleder,Filip K. Swirski +22 more
TL;DR: Macrophage proliferation is revealed as a key event in atherosclerosis and macrophage self-renewal is identified as a therapeutic target for cardiovascular disease.
Journal Article
Differential Activation of Cyclophosphamide and Ifosphamide by Cytochromes P-450 2B and 3A in Human Liver Microsomes
TL;DR: It is established that liver microsomal CYP2B and CYP3A preferentially catalyze cyclophosphamide and ifosphamide 4-hydroxylation, respectively, suggesting that liver P-450-inducing agents targeted at these enzymes might be used in cancer patients to enhance drug activation and therapeutic efficacy.
Journal ArticleDOI
Extramedullary Hematopoiesis Generates Ly-6C(high) Monocytes That Infiltrate Atherosclerotic Lesions
Clinton S. Robbins,Aleksey Chudnovskiy,Philipp J. Rauch,Jose-Luiz Figueiredo,Yoshiko Iwamoto,Rostic Gorbatov,Martin Etzrodt,Georg F. Weber,Takuya Ueno,Nico van Rooijen,Mary Jo Mulligan-Kehoe,Peter Libby,Matthias Nahrendorf,Mikael J. Pittet,Ralph Weissleder,Filip K. Swirski +15 more
TL;DR: The findings indicate that extramedullary sites supplement the hematopoietic function of the bone marrow by producing circulating inflammatory cells that infiltrate atherosclerotic lesions.