George Crotts

TL;DR: In this article, a simple method to prepare various porous and nonporous hollow microspheres composed of poly( d,l -lactic-co-glycolic acid) using a water/oil/water (W/O/W) multiple emulsion solvent evaporation technique is described.

TL;DR: Two proteins, carbonic anhydrase and bovine serum albumin, have been encapsulated as model protein drugs within microspheres composed of relatively fast degrading poly(d,l-lactic acid-co-glycolic acid, 50/50) to investigate protein stability problems.

TL;DR: In this paper, size exclusion chromatographic analysis of bovine serum albumin (BSA) encapsulated within microparticles revealed that the covalent aggregation of BSA significantly occurred during the encapsulation process and throughout a release study.

TL;DR: It was found that a non-specific adsorption of encapsulated protein molecules onto the expanding polymeric surface of both microspheres severely limited the amount of protein available for release, resulting in slow and incomplete release profiles.

TL;DR: In this paper , the authors present a survey report based on a confidential survey and following discussions by 16 globally acting major biotechnology companies on various aspects of polysorbates (PS) and discuss the current practice and use of PS during manufacture across their global manufacturing sites in addition to aspects like current understanding of the (in)stability of PS, the routine QC testing and control of PS.