抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

We present a full-sky 100 μm map that is a reprocessed composite of the COBE/DIRBE and IRAS/ISSA maps, with the zodiacal foreground and confirmed point sources removed. Before using the ISSA maps, we remove the remaining artifacts from the IRAS scan pattern. Using the DIRBE 100 and 240 μm data, we have constructed a map of the dust temperature so that the 100 μm map may be converted to a map proportional to dust column density. The dust temperature varies from 17 to 21 K, which is modest but does modify the estimate of the dust column by a factor of 5. The result of these manipulations is a map with DIRBE quality calibration and IRAS resolution. A wealth of filamentary detail is apparent on many different scales at all Galactic latitudes. In high-latitude regions, the dust map correlates well with maps of H I emission, but deviations are coherent in the sky and are especially conspicuous in regions of saturation of H I emission toward denser clouds and of formation of H2 in molecular clouds. In contrast, high-velocity H I clouds are deficient in dust emission, as expected. To generate the full-sky dust maps, we must first remove zodiacal light contamination, as well as a possible cosmic infrared background (CIB). This is done via a regression analysis of the 100 μm DIRBE map against the Leiden-Dwingeloo map of H I emission, with corrections for the zodiacal light via a suitable expansion of the DIRBE 25 μm flux. This procedure removes virtually all traces of the zodiacal foreground. For the 100 μm map no significant CIB is detected. At longer wavelengths, where the zodiacal contamination is weaker, we detect the CIB at surprisingly high flux levels of 32 ± 13 nW m-2 sr-1 at 140 μm and of 17 ± 4 nW m-2 sr-1 at 240 μm (95% confidence). This integrated flux ~2 times that extrapolated from optical galaxies in the Hubble Deep Field. The primary use of these maps is likely to be as a new estimator of Galactic extinction. To calibrate our maps, we assume a standard reddening law and use the colors of elliptical galaxies to measure the reddening per unit flux density of 100 μm emission. We find consistent calibration using the B-R color distribution of a sample of the 106 brightest cluster ellipticals, as well as a sample of 384 ellipticals with B-V and Mg line strength measurements. For the latter sample, we use the correlation of intrinsic B-V versus Mg2 index to tighten the power of the test greatly. We demonstrate that the new maps are twice as accurate as the older Burstein-Heiles reddening estimates in regions of low and moderate reddening. The maps are expected to be significantly more accurate in regions of high reddening. These dust maps will also be useful for estimating millimeter emission that contaminates cosmic microwave background radiation experiments and for estimating soft X-ray absorption. We describe how to access our maps readily for general use.

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Maps of Dust Infrared Emission for Use in Estimation of Reddening and Cosmic Microwave Background Radiation Foregrounds

We review recent determinations of the present-day mass function (PDMF) and initial mass function (IMF) in various components of the Galaxy—disk, spheroid, young, and globular clusters—and in conditions characteristic of early star formation. As a general feature, the IMF is found to depend weakly on the environment and to be well described by a power-law form forM , and a lognormal form below, except possibly for m!1 early star formation conditions. The disk IMF for single objects has a characteristic mass around M , m!0.08 c and a variance in logarithmic mass , whereas the IMF for multiple systems hasM , and . j!0.7 m!0.2 j!0.6 c The extension of the single MF into the brown dwarf regime is in good agreement with present estimates of L- and T-dwarf densities and yields a disk brown dwarf number density comparable to the stellar one, n!n! BD " pc !3 .T he IMF of young clusters is found to be consistent with the disk fi eld IMF, providing the same correction 0.1 for unresolved binaries, confirming the fact that young star clusters and disk field stars represent the same stellar population. Dynamical effects, yielding depletion of the lowest mass objects, are found to become consequential for ages!130 Myr. The spheroid IMF relies on much less robust grounds. The large metallicity spread in the local subdwarf photometric sample, in particular, remains puzzling. Recent observations suggest that there is a continuous kinematic shear between the thick-disk population, present in local samples, and the genuine spheroid one. This enables us to derive only an upper limit for the spheroid mass density and IMF. Within all the uncertainties, the latter is found to be similar to the one derived for globular clusters and is well represented also by a lognormal form with a characteristic mass slightly larger than for the disk, M , ,e xcluding as ignif icant population of m!0.2-0.3 c brown dwarfs in globular clusters and in the spheroid. The IMF characteristic of early star formation at large redshift remains undetermined, but different observational constraints suggest that it does not extend below!1M , .T hese results suggest a characteristic mass for star formation that decreases with time, from conditions prevailing at large redshift to conditions characteristic of the spheroid (or thick disk) to present-day conditions.Theseconclusions,however, remain speculative, given the large uncertainties in the spheroid and early star IMF determinations. These IMFs allow a reasonably robust determination of the Galactic present-day and initial stellar and brown dwarf contents. They also have important galactic implications beyond the Milky Way in yielding more accurate mass-to-light ratio determinations. The mass-to-light ratios obtained with the disk and the spheroid IMF yield values 1.8-1.4 times smaller than for a Salpeter IMF, respectively, in agreement with various recent dynamical determinations. This general IMF determination is examined in the context of star formation theory. None of the theories based on a Jeans-type mechanism, where fragmentation is due only to gravity, can fulfill all the observational constraints on star formation and predict a large number of substellar objects. On the other hand, recent numerical simulations of compressible turbulence, in particular in super-Alfvenic conditions, seem to reproduce both qualitatively and quantitatively the stellar and substellar IMF and thus provide an appealing theoretical foundation. In this picture, star formation is induced by the dissipation of large-scale turbulence to smaller scales through radiative MHD shocks, producing filamentary structures. These shocks produce local nonequilibrium structures with large density contrasts, which collapse eventually in gravitationally bound objects under the combined influence of turbulence and gravity. The concept of a single Jeans mass is replaced by a distribution of local Jeans masses, representative of the lognormal probability density function of the turbulent gas. Objects below the mean thermal Jeans mass still have a possibility to collapse, although with a decreasing probability.

/pdf/galactic-stellar-and-substellar-initial-mass-function-1fntlgtk9q.pdf

Galactic stellar and substellar initial mass function

The all sky surveys done by the Palomar Observatory Schmidt, the European Southern Observatory Schmidt, and the United Kingdom Schmidt, the InfraRed Astronomical Satellite and the 2 Micron All Sky Survey have proven to be extremely useful tools for astronomy with value that lasts for decades. The Wide-field Infrared Survey Explorer is mapping the whole sky following its launch on 14 December 2009. WISE began surveying the sky on 14 Jan 2010 and completed its first full coverage of the sky on July 17. The survey will continue to cover the sky a second time until the cryogen is exhausted (anticipated in November 2010). WISE is achieving 5 sigma point source sensitivities better than 0.08, 0.11, 1 and 6 mJy in unconfused regions on the ecliptic in bands centered at wavelengths of 3.4, 4.6, 12 and 22 micrometers. Sensitivity improves toward the ecliptic poles due to denser coverage and lower zodiacal background. The angular resolution is 6.1", 6.4", 6.5" and 12.0" at 3.4, 4.6, 12 and 22 micrometers, and the astrometric precision for high SNR sources is better than 0.15".

/pdf/the-wide-field-infrared-survey-explorer-wise-mission-2r7j8rzri4.pdf

The wide-field infrared survey explorer (wise): mission description and initial on-orbit performance

A universal initial mass function (IMF) is not intuitive, but so far no convincing evidence for a variable IMF exists. The detection of systematic variations of the IMF with star-forming conditions would be the Rosetta Stone for star formation.



In this contribution an average or Galactic-field IMF is defined, stressing that there is evidence for a change in the power-law index at only two masses: near 0.5 M⊙ and near 0.08 M⊙. Using this supposed universal IMF, the uncertainty inherent in any observational estimate of the IMF is investigated by studying the scatter introduced by Poisson noise and the dynamical evolution of star clusters. It is found that this apparent scatter reproduces quite well the observed scatter in power-law index determinations, thus defining the fundamental limit within which any true variation becomes undetectable. The absence of evidence for a variable IMF means that any true variation of the IMF in well-studied populations must be smaller than this scatter.



Determinations of the power-law indices α are subject to systematic errors arising mostly from unresolved binaries. The systematic bias is quantified here, with the result that the single-star IMFs for young star clusters are systematically steeper by Δα≈0.5 between 0.1 and 1 M⊙ than the Galactic-field IMF, which is populated by, on average, about 5-Gyr-old stars. The MFs in globular clusters appear to be, on average, systematically flatter than the Galactic-field IMF (Piotto & Zoccali; Paresce & De Marchi), and the recent detection of ancient white-dwarf candidates in the Galactic halo and the absence of associated low-mass stars (Ibata et al.; Mendez & Minniti) suggest a radically different IMF for this ancient population. Star formation in higher metallicity environments thus appears to produce relatively more low-mass stars. While still tentative, this is an interesting trend, being consistent with a systematic variation of the IMF as expected from theoretical arguments.

/pdf/on-the-variation-of-the-initial-mass-function-30qbs7h433.pdf

On the variation of the initial mass function

John Mather (NASA/GSFC, chair) Mark Clampin (NASA/GSFC) Rene Doyon (U. of Montreal) Kathy Flanagan (STScI) Marijn Franx (Leiden U.) Jonathan Gardner (NASA/GSFC) Matthew Greenhouse (NASA/GSFC) Heidi Hammel (SSI) John Hutchings (Herzberg I. of A.) Peter Jakobsen (ESA) Simon Lilly (ETH-Zurich) Mark McCaughrean (U. of Exeter) Matt Mountain (STScI) George Rieke (U. of Arizona) George Sonneborn (NASA/GSFC) Rogier Windhorst (Arizona State U.) Gillian Wright (UK ATC)

/pdf/first-light-and-reionization-open-questions-in-the-post-jwst-1tgfoz0bgx.pdf

First light and reionization : open questions in the post-JWST era

New AFCRL IR Sources

The behavior of the aromatic features as a function of metallicity/radiation field hardness in M101 HII regions and starburst galaxies is investigated using Spitzer/IRS spectra. These spectra reveal that the 6.2, 7.8+8.6, and 11.3 micron aromatics have different dependencies on metallicity/radiation field hardness. Specifically, the 6.2 and 7.8+8.6 micron aromatics are weak or absent at a metallicity, 12+log(O/H), of approx. 8.0 while the 11.3 micron feature remains relatively strong. These results apply to both the M101 HII regions and starbursts showing that HII regions can indeed be thought of as ``mini-starbursts.'' Comparison of this work with various candidate materials results in a good match with the annealing behavior in Quenched Carbonaceous Composite (QCC) which is an amorphous, hydrogenated, carbonaceous solid.

Aromatic Features in M101 HII Regions and Starburst Galaxies

The JWST Mid-Infrared Instrument (MIRI) detector arrays are Si:As blocked impurity band devices, direct descendants of the Spitzer/IRAC long wavelength arrays. Similarly to the IRAC row-column effect, analysis of flightlike MIRI detector data has shown that columns and rows in which source signals are located can suffer from pull up (brightness increase) or pull down (brightness decrease) in the flux image. Here we present results from the JPL MIRI detector characterisation campaigns dedicated to understanding this row-column effect as well as the first results showing the effect in the flight detectors for MIRI. We show the effect is flux dependent and confirm that the effect manifests differently for rows versus columns. We discuss the origin of the flux offset, which is related to a change in the signal output in time that distorts the input ramp as a function of the saturation level of illuminated pixels. We conclude by discussing the row-column effect in the context of different MIRI instrument modes and present preliminary proposals to mitigate and/or correct the effect in MIRI data.

Row and column artifacts in JWST MIRI’s Si:As blocked impurity band detectors

We have surveyed the 30 Myr-old cluster NGC 2547 for planetary debris disks using Spitzer. At 4.5-8 um we are sensitive to the photospheric level down to mid-M stars (0.2 Msol) and at 24 um to early-G stars (1.2 Msol). We find only two to four stars with excesses at 8 um out of ~400-500 cluster members, resulting in an excess fraction <~1 percent at this wavelength. By contrast, the excess fraction at 24 um is ~40 percent (for B-F types). Out of four late-type stars with excesses at 8 um two marginal ones are consistent with asteroid-like debris disks. Among stars with strong 8 um excesses one is possibly from a transitional disk, while another one can be a result of a catastrophic collision. Our survey demonstrates that the inner 0.1-1 AU parts of disks around solar-type stars clear out very thoroughly by 30 Myrs of age. Comparing with the much slower decay of excesses at 24 and 70 um, disks clear from the inside out, of order 10 Myr for the inner zones probed at 8 um compared with a hundred or more Myr for those probed with the two longer wavelengths.

George H. Rieke

Papers

First light and reionization : open questions in the post-JWST era

New AFCRL IR Sources

Aromatic Features in M101 HII Regions and Starburst Galaxies

Row and column artifacts in JWST MIRI’s Si:As blocked impurity band detectors

Debris Disks in NGC 2547