G
George H. Rothblat
Researcher at Children's Hospital of Philadelphia
Publications - 12
Citations - 3839
George H. Rothblat is an academic researcher from Children's Hospital of Philadelphia. The author has contributed to research in topics: Cholesterol & Reverse cholesterol transport. The author has an hindex of 11, co-authored 12 publications receiving 3591 citations. Previous affiliations of George H. Rothblat include University of Pennsylvania & Drexel University.
Papers
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Journal ArticleDOI
Cholesterol efflux capacity, high-density lipoprotein function, and atherosclerosis
Amit Khera,Marina Cuchel,Margarita de la Llera-Moya,Amrith Rodrigues,Megan F. Burke,Kashif Jafri,Benjamin French,Julie A. Phillips,Megan L. Mucksavage,Robert L. Wilensky,Emile R. Mohler,George H. Rothblat,Daniel J. Rader +12 more
TL;DR: Cholesterol efflux capacity from macrophages, a metric of HDL function, has a strong inverse association with both carotid intima-media thickness and the likelihood of angiographic coronary artery disease, independently of the HDL cholesterol level.
Journal ArticleDOI
Importance of Different Pathways of Cellular Cholesterol Efflux
Patricia G. Yancey,Anna E. Bortnick,Ginny Kellner-Weibel,Margarita de la Llera-Moya,Michael C. Phillips,George H. Rothblat +5 more
TL;DR: The relative importance of the SR-BI and ABCA1 efflux pathways in preventing the development of atherosclerotic plaque is not known but will depend on the expression levels of the two proteins and on the type of cholesterol acceptors available.
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Hepatic expression of scavenger receptor class B type I (SR-BI) is a positive regulator of macrophage reverse cholesterol transport in vivo
Yuzhen Zhang,Jaqueline R. Da Silva,Muredach P. Reilly,Jeffrey T. Billheimer,George H. Rothblat,Daniel J. Rader +5 more
TL;DR: It is demonstrated that hepatic SR-BI expression, despite its inverse effects on steady-state plasma HDL cholesterol concentrations, is an important positive regulator of the rate of macrophage RCT.
Journal ArticleDOI
The roles of different pathways in the release of cholesterol from macrophages.
Maria Pia Adorni,Francesca Zimetti,Jeffrey T. Billheimer,Nan Wang,Daniel J. Rader,Michael C. Phillips,George H. Rothblat +6 more
TL;DR: These studies demonstrate that the aqueous diffusion mechanism is one of the major contributors to efflux, particularly in cholesterol-normal cells.
Journal ArticleDOI
Differential effects of HDL subpopulations on cellular ABCA1- and SR-BI-mediated cholesterol efflux.
Bela F. Asztalos,Margarita de la Llera-Moya,Gerard E. Dallal,Katalin V. Horvath,Ernst J. Schaefer,George H. Rothblat +5 more
TL;DR: Data demonstrate that the small, lipid-poor preβ-1 HDL has the strongest association with ABCA1-mediated cholesterol even in the presence of all other HDL subpopulations.