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Robert L. Wilensky
Researcher at University of Pennsylvania
Publications - 220
Citations - 21826
Robert L. Wilensky is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Percutaneous coronary intervention & Myocardial infarction. The author has an hindex of 63, co-authored 216 publications receiving 20267 citations. Previous affiliations of Robert L. Wilensky include Indiana University – Purdue University Indianapolis & University of Washington.
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Journal ArticleDOI
Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes.
Struan F.A. Grant,Gudmar Thorleifsson,Inga Reynisdottir,Rafil Benediktsson,Andrei Manolescu,Jesus Sainz,Agnar Helgason,Hreinn Stefansson,Valur Emilsson,Anna Helgadottir,Unnur Styrkarsdottir,Kristinn P. Magnusson,G. Bragi Walters,Ebba Palsdottir,Thorbjorg Jonsdottir,Thorunn Gudmundsdottir,Arnaldur Gylfason,Jona Saemundsdottir,Robert L. Wilensky,Muredach P. Reilly,Daniel J. Rader,Yu Z. Bagger,Claus Christiansen,Vilmundur Gudnason,Gunnar Sigurdsson,Unnur Thorsteinsdottir,Jeffrey R. Gulcher,Augustine Kong,Kari Stefansson +28 more
TL;DR: A microsatellite within intron 3 of the transcription factor 7–like 2 gene (TCF7L2; formerly TCF4) was associated with type 2 diabetes mellitus and is thought to act through regulation of proglucagon gene expression in enteroendocrine cells via the Wnt signaling pathway.
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Cholesterol efflux capacity, high-density lipoprotein function, and atherosclerosis
Amit Khera,Marina Cuchel,Margarita de la Llera-Moya,Amrith Rodrigues,Megan F. Burke,Kashif Jafri,Benjamin French,Julie A. Phillips,Megan L. Mucksavage,Robert L. Wilensky,Emile R. Mohler,George H. Rothblat,Daniel J. Rader +12 more
TL;DR: Cholesterol efflux capacity from macrophages, a metric of HDL function, has a strong inverse association with both carotid intima-media thickness and the likelihood of angiographic coronary artery disease, independently of the HDL cholesterol level.
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Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants.
Sekar Kathiresan,Benjamin F. Voight,Shaun Purcell,Kiran Musunuru,Diego Ardissino,Pier Mannuccio Mannucci,Sonia S. Anand,James C. Engert,Nilesh J. Samani,Heribert Schunkert,Jeanette Erdmann,Muredach P. Reilly,Daniel J. Rader,Thomas M. Morgan,John A. Spertus,Monika Stoll,Domenico Girelli,Pascal P. McKeown,Christopher Patterson,David S. Siscovick,Christopher J. O'Donnell,Roberto Elosua,Leena Peltonen,Veikko Salomaa,Stephen M. Schwartz,Olle Melander,David Altshuler,Pier Angelica Merlini,Carlo Berzuini,Luisa Bernardinelli,Flora Peyvandi,Marco Tubaro,Patrizia Celli,Maurizio Ferrario,Raffaela Fetiveau,Nicola Marziliano,Giorgio Casari,Michele Galli,Flavio Ribichini,Marco Rossi,Francesco Bernardi,Pietro Zonzin,Alberto Piazza,Jean Yee,Yechiel Friedlander,Jaume Marrugat,Gavin Lucas,Isaac Subirana,Joan Sala,Rafael Ramos,James B. Meigs,Gordon H. Williams,David M. Nathan,Calum A. MacRae,Aki S. Havulinna,Göran Berglund,Joel N. Hirschhorn,Rosanna Asselta,Stefano Duga,Marta Spreafico,Mark J. Daly,James Nemesh,Joshua M. Korn,Steven A. McCarroll,Aarti Surti,Candace Guiducci,Lauren Gianniny,Daniel B. Mirel,Melissa Parkin,Noël P. Burtt,Stacey Gabriel,John R. Thompson,Peter S. Braund,Benjamin J. Wright,Anthony J. Balmforth,Stephen G. Ball,Alistair S. Hall,Patrick Linsel-Nitschke,Wolfgang Lieb,Andreas Ziegler,Inke R. König,Christian Hengstenberg,Marcus Fischer,Klaus Stark,Anika Grosshennig,Michael Preuss,H-Erich Wichmann,Stefan Schreiber,Willem H. Ouwehand,Panos Deloukas,Michael Scholz,François Cambien,Mingyao Li,Zhen Chen,Robert L. Wilensky,William H. Matthai,Atif Qasim,Hakon Hakonarson,Joe Devaney,Mary-Susan Burnett,Augusto D. Pichard,Kenneth M. Kent,Lowell F. Satler,Joseph M. Lindsay,Ron Waksman,Stephen E. Epstein,Thomas Scheffold,Klaus Berger,Andreas Huge,Nicola Martinelli,Oliviero Olivieri,Roberto Corrocher,Hilma Holm,Gudmar Thorleifsson,Unnur Thorsteinsdottir,Kari Stefansson,Ron Do,Changchun Xie,David S. Siscovick +118 more
TL;DR: SNPs at nine loci were reproducibly associated with myocardial infarction, but tests of common and rare CNVs failed to identify additional associations with my Cardiovascular Infarction risk.
Journal ArticleDOI
A variant in CDKAL1 influences insulin response and risk of type 2 diabetes.
Valgerdur Steinthorsdottir,Gudmar Thorleifsson,Inga Reynisdottir,Rafn Benediktsson,Thorbjorg Jonsdottir,G. Bragi Walters,Unnur Styrkarsdottir,Solveig Gretarsdottir,Valur Emilsson,Shyamali Ghosh,Adam Baker,Steinunn Snorradottir,Hjordis Bjarnason,Maggie C.Y. Ng,Torben Hansen,Yu Z. Bagger,Robert L. Wilensky,Muredach P. Reilly,Adebowale Adeyemo,Yuanxiu Chen,Jie Zhou,Vilmundur Gudnason,Guanjie Chen,Hanxia Huang,Kerrie Lashley,Ayo Doumatey,Wing-Yee So,Ronald Ching-Wa Ma,Gitte Andersen,Knut Borch-Johnsen,Knut Borch-Johnsen,Knut Borch-Johnsen,Torben Jørgensen,Jana V. van Vliet-Ostaptchouk,Marten H. Hofker,Marten H. Hofker,Cisca Wijmenga,Cisca Wijmenga,Claus Christiansen,Daniel J. Rader,Charles N. Rotimi,Mark E. Gurney,Juliana C.N. Chan,Oluf Pedersen,Oluf Pedersen,Gunnar Sigurdsson,Jeffrey R. Gulcher,Unnur Thorsteinsdottir,Augustine Kong,Kari Stefansson +49 more
TL;DR: A genome-wide association study for type 2 diabetes (T2D) in Icelandic cases and controls is conducted, and it is found that a previously described variant in the transcription factor 7-like 2 gene (TCF7L2) gene conferred the most significant risk.
Journal ArticleDOI
Stent-Based Delivery of Sirolimus Reduces Neointimal Formation in a Porcine Coronary Model
Takeshi Suzuki,Greg Kopia,Shin Ichiro Hayashi,Lynn Bailey,Gerard H. Llanos,Robert L. Wilensky,Bruce D. Klugherz,George Papandreou,Pallassana Narayan,Martin B. Leon,Alan C. Yeung,Fermin O. Tio,Philip S. Tsao,Robert Falotico,Andrew J. Carter +14 more
TL;DR: Stent-based delivery of SRL via a nonerodable polymer matrix is feasible and effectively reduces in-stent neointimal hyperplasia by inhibiting cellular proliferation.