G
George Kastellakis
Researcher at Foundation for Research & Technology – Hellas
Publications - 14
Citations - 548
George Kastellakis is an academic researcher from Foundation for Research & Technology – Hellas. The author has contributed to research in topics: Engram & Encoding (memory). The author has an hindex of 7, co-authored 14 publications receiving 355 citations. Previous affiliations of George Kastellakis include University of Crete.
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Journal ArticleDOI
Synaptic clustering within dendrites: an emerging theory of memory formation.
TL;DR: Recent findings regarding the subcellular mechanisms implicated in memory formation provide evidence for a dendrite-centered theory of memory, and both experimental evidence and theoretical models that support this hypothesis are discussed.
Journal ArticleDOI
Hotspots of dendritic spine turnover facilitate clustered spine addition and learning and memory
Adam C. Frank,Shan Huang,Miou Zhou,Amos Gdalyahu,Amos Gdalyahu,George Kastellakis,Tawnie K. Silva,Elaine Lu,Ximiao Wen,Panayiota Poirazi,Joshua T. Trachtenberg,Alcino J. Silva +11 more
TL;DR: A hotspot model where spine turnover is the driver for localization of clustered spine formation, which serves to modulate network function, thus influencing storage capacity and L&M is supported.
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Linking Memories across Time via Neuronal and Dendritic Overlaps in Model Neurons with Active Dendrites
TL;DR: A simplified, biophysically inspired network model that incorporates multiple plasticity processes and explains linking of information at three different levels is developed, revealing a simple, unifying principle: linked memories share synaptic clusters within the dendrites of overlapping populations of neurons.
Journal ArticleDOI
Challenging the point neuron dogma: FS basket cells as 2-stage nonlinear integrators.
Alexandra Tzilivaki,Alexandra Tzilivaki,Alexandra Tzilivaki,George Kastellakis,Panayiota Poirazi +4 more
TL;DR: It is shown, through detailed biophysical modeling, that fast spiking interneurons are better described with a 2-stage artificial neural network model calling into question the use of point neuron models.
Journal ArticleDOI
Synaptic Clustering and Memory Formation.
TL;DR: This review focuses on recent evidence which investigates the role of synapse clustering in dendritic integration, sensory perception, learning, and memory as well as brain dysfunction.