J
Joshua T. Trachtenberg
Researcher at University of California, Los Angeles
Publications - 49
Citations - 8671
Joshua T. Trachtenberg is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Visual cortex & Receptive field. The author has an hindex of 30, co-authored 46 publications receiving 7801 citations. Previous affiliations of Joshua T. Trachtenberg include University of Texas at Austin & Semel Institute for Neuroscience and Human Behavior.
Papers
More filters
Journal ArticleDOI
Long-term in vivo imaging of experience-dependent synaptic plasticity in adult cortex
Joshua T. Trachtenberg,Brian E. Chen,Graham Knott,Guoping Feng,Joshua R. Sanes,Egbert Welker,Karel Svoboda +6 more
TL;DR: The measurements suggest that sensory experience drives the formation and elimination of synapses and that these changes might underlie adaptive remodelling of neural circuits.
Journal ArticleDOI
Transient and Persistent Dendritic Spines in the Neocortex In Vivo
Anthony Holtmaat,Joshua T. Trachtenberg,Linda Wilbrecht,Gordon M. Shepherd,Xiaoqun Zhang,Graham Knott,Karel Svoboda +6 more
TL;DR: In 6-month-old mice, spines turn over more slowly in visual compared to somatosensory cortex, possibly reflecting differences in the capacity for experience-dependent plasticity in these brain regions.
Journal ArticleDOI
Long-term, high-resolution imaging in the mouse neocortex through a chronic cranial window
Anthony Holtmaat,Anthony Holtmaat,Tobias Bonhoeffer,David K. Chow,JA Chuckowree,Vincenzo De Paola,Vincenzo De Paola,Sonja B. Hofer,Sonja B. Hofer,Mark Hübener,Tara Keck,Graham Knott,Graham Knott,Wei-Chung Allen Lee,Ricardo Mostany,Thomas D. Mrsic-Flogel,Thomas D. Mrsic-Flogel,Elly Nedivi,Carlos Portera-Cailliau,Karel Svoboda,Karel Svoboda,Joshua T. Trachtenberg,Linda Wilbrecht,Linda Wilbrecht +23 more
TL;DR: A chronic cranial window is described to obtain optical access to the mouse cerebral cortex for long-term imaging and the entire dendritic and axonal arbor of individual neurons can be reconstructed.
Journal ArticleDOI
Absence of CNTNAP2 Leads to Epilepsy, Neuronal Migration Abnormalities, and Core Autism-Related Deficits
Olga Peñagarikano,Brett S. Abrahams,Brett S. Abrahams,Edward I. Herman,Kellen D. Winden,Amos Gdalyahu,Hongmei Dong,Lisa I. Sonnenblick,Robin Gruver,Joel Almajano,Anatol Bragin,Peyman Golshani,Joshua T. Trachtenberg,Elior Peles,Daniel H. Geschwind,Daniel H. Geschwind +15 more
TL;DR: A mouse knockout of the Cntnap2 gene is characterized, which is strongly associated with ASD and allied neurodevelopmental disorders, and treatment with the FDA-approved drug risperidone ameliorates the targeted repetitive behaviors in the mutant mice.
Journal ArticleDOI
A disinhibitory microcircuit initiates critical-period plasticity in the visual cortex
Sandra J. Kuhlman,Nicholas D. Olivas,Elaine Tring,Taruna Ikrar,Xiangmin Xu,Joshua T. Trachtenberg +5 more
TL;DR: These findings define the microcircuit changes initiating competitive plasticity during critical periods of cortical development and show that the restoration of evoked firing rates of layer 2/3 pyramidal neurons by PV-specific disinhibition is a key step in the progression of ODP.