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George Kokotos
Researcher at National and Kapodistrian University of Athens
Publications - 207
Citations - 5006
George Kokotos is an academic researcher from National and Kapodistrian University of Athens. The author has contributed to research in topics: Amino acid & Phospholipase A2. The author has an hindex of 37, co-authored 196 publications receiving 4522 citations. Previous affiliations of George Kokotos include Agricultural University of Athens & McGill University.
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Phospholipase A2 enzymes: physical structure, biological function, disease implication, chemical inhibition, and therapeutic intervention.
TL;DR: The phospholipase A2 (PLA2) superfamily traces its roots to the identification of lytic actions of snake venom at the end of the 19th century and to the late 1980’s when PLA2-like activities were reported in mammalian cells in contrast to extracellular secreted activities from venom and pancreas.
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Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-6.
Arduino A. Mangoni,Catherine Guillou,Jean Jacques Vanden Eynde,Christopher Hulme,Josef Jampilek,Wei Li,Katalin Prokai-Tatrai,Jarkko Rautio,Simona Collina,Tiziano Tuccinardi,Maria Emília Sousa,Jean-Marc Sabatier,Stefania Galdiero,Rafik Karaman,Rafik Karaman,George Kokotos,Giangiacomo Torri,F. Javier Luque,M. Helena Vasconcelos,Dimitra Hadjipavlou-Litina,Carlo Siciliano,Michael Gütschow,Rino Ragno,Paula Gomes,Luigi A. Agrofoglio,Diego Muñoz-Torrero +25 more
TL;DR: Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes is a series of Editorials published on a biannual basis by the Editorial Board of the Medicinal chemistry section of the journal Molecules.
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Phospholipase A2 inhibitors as potential therapeutic agents for the treatment of inflammatory diseases.
Victoria Magrioti,George Kokotos +1 more
TL;DR: Although the role of each PLA2 is not yet distinct in different diseases, the development and future use of different PLA2 inhibitors to treat human disease seems very promising.
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Autotaxin, a secreted lysophospholipase D, as a promising therapeutic target in chronic inflammation and cancer.
TL;DR: The present review article aims to summarize the existing knowledge as to the implications of ATX in chronic inflammatory diseases and cancer and to highlight the low molecular weight compounds, which have been developed as leads for the discovery of novel medicines to treat inflammatory diseasesand cancer.
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Synthetic and natural inhibitors of phospholipases A2: their importance for understanding and treatment of neurological disorders.
TL;DR: The purpose of this review is to summarize information on selective and potent synthetic inhibitors of PLA2 as well as several PLA2 inhibitors from plants, for treatment of oxidative stress and neuroinflammation associated with the pathogenesis of neurological disorders.