J
Jarkko Rautio
Researcher at University of Eastern Finland
Publications - 89
Citations - 5400
Jarkko Rautio is an academic researcher from University of Eastern Finland. The author has contributed to research in topics: Prodrug & Amino acid. The author has an hindex of 31, co-authored 83 publications receiving 4538 citations. Previous affiliations of Jarkko Rautio include University of London & Research Triangle Park.
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Journal ArticleDOI
Prodrugs: design and clinical applications
Jarkko Rautio,Hanna Kumpulainen,Tycho Heimbach,Reza Oliyai,Doo-Man Oh,Tomi Järvinen,Jouko Savolainen +6 more
TL;DR: The most common functional groups that are amenable to prodrug design are described, and examples of prodrugs that are either launched or are undergoing human trials are highlighted.
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Prodrugs—from Serendipity to Rational Design
TL;DR: The rationale behind the use of the prodrug approach from past to present is introduced, and the possible problems that can arise from inadequate activation of prodrugs are considered.
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The expanding role of prodrugs in contemporary drug design and development
TL;DR: This Review highlights prodrug design strategies for improved formulation and pharmacokinetic and targeting properties, with a focus on the most recently marketed prodrugs.
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In vitro p-glycoprotein inhibition assays for assessment of clinical drug interaction potential of new drug candidates: a recommendation for probe substrates
Jarkko Rautio,Joan E. Humphreys,Lindsey O. Webster,Anand Balakrishnan,John P. Keogh,Jeevan R. Kunta,Cosette J. Serabjit-Singh,Joseph W. Polli +7 more
TL;DR: It is recommended that digoxin be considered as the standard in vitro probe to investigate the inhibition profiles of new drug candidates and shows that it may not be necessary to generate IC50 values with multiple probe substrates for Pgp as is currently done for cytochrome P450 3A4.
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Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-6.
Arduino A. Mangoni,Catherine Guillou,Jean Jacques Vanden Eynde,Christopher Hulme,Josef Jampilek,Wei Li,Katalin Prokai-Tatrai,Jarkko Rautio,Simona Collina,Tiziano Tuccinardi,Maria Emília Sousa,Jean-Marc Sabatier,Stefania Galdiero,Rafik Karaman,Rafik Karaman,George Kokotos,Giangiacomo Torri,F. Javier Luque,M. Helena Vasconcelos,Dimitra Hadjipavlou-Litina,Carlo Siciliano,Michael Gütschow,Rino Ragno,Paula Gomes,Luigi A. Agrofoglio,Diego Muñoz-Torrero +25 more
TL;DR: Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes is a series of Editorials published on a biannual basis by the Editorial Board of the Medicinal chemistry section of the journal Molecules.