Showing papers by "George Stoica published in 2014"
TL;DR: Vineatrol(®) 30, resveratrol, hopeaphenol and r2-viniferin inhibited the growth of D-GBM and DH82 cells in a concentration-dependent manner, whereby hopeapheol and R2-Viniferin were more potent than resver atrol itself in inhibiting the Growth of the canine tumour cell lines.
Abstract: Vineatrol(®) 30 is a grapevine-shoot extract, which contains resveratrol as well as considerable amounts of so-called resveratrol oligomers such as hopeaphenol and r2-viniferin. In this study, we analysed whether the two above-mentioned resveratrol oligomers were able to inhibit the growth of the canine glioblastoma cell line D-GBM and the canine histiocytic sarcoma cell line DH82, compared their potency to inhibit tumour cell growth with that of resveratrol and determined whether the induction of apoptosis via caspase 9 and 3/7 activation underlies the tumour cell growth-inhibiting effect of hopeaphenol and r2-viniferin. Vineatrol(®) 30, resveratrol, hopeaphenol and r2-viniferin inhibited the growth of D-GBM and DH82 cells in a concentration-dependent manner, whereby hopeaphenol and r2-viniferin were more potent than resveratrol itself in inhibiting the growth of the canine tumour cell lines. Moreover, the anti-proliferative effect of both resveratrol oligomers in D-GBM cells is based on their capacity to induce caspase 9 and 3/7 activation.
25 citations
TL;DR: In this article, an ion mobility mass spectrometer (IMMS) was used to study the striatal metabolomes in a Parkinson's like disease (PD-like) rat model.
Abstract: Electrospray ionization ion mobility mass spectrometry (ESI-IMMS) was used to study the striatal metabolomes in a Parkinson’s like disease (PD-like) rat model. Striatal tissue samples from Berlin Druckrey IV (BD-IV) with PD-like disease 20 dpn-affected and 15 dpn-affected rats (dpn: days postnatal) were investigated and compared with age-matched controls. An ion mobility mass spectrometer (IMMS) produced multidimensional spectra with mass to charge ratio (m/z), ion mobility drift time, and intensity information for each individual metabolite. Principle component analysis (PCA) was applied in this study for pattern recognition and significant metabolites selection (68% data was modeled in PCA). Both IMMS spectra and PCA results showed that there were clear global metabolic differences between PD-like samples and healthy controls. Nine metabolites were selected by PCA and identified as potential biomarkers using the Human Metabolome Database (HMDB). One targeted metabolite in this study was dopamine. Select...
20 citations
01 Oct 2014
TL;DR: This paper proposes an implementation model for GPU architectures and highlights the advantages over the CPU version, using nVidia's CUDA platform.
Abstract: Due to their inherent architecture, the discrete time model of Cellular nonlinear networks (CNNs) for image processing are well suited candidates for efficient implementation using massively parallel architectures. This paper proposes an implementation model for GPU architectures and highlights the advantages over the CPU version, using nVidia's CUDA platform.
4 citations
01 Jan 2014
TL;DR: Matrix metalloproteinase 2 (MMP2) is important in breast cancer invasion and metastasis and its role in prognosis is still unclear.
Abstract: Matrix metalloproteinase 2 (MMP2) is important in breast cancer (BC) invasion and metastasis.
2 citations