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Wolfgang Baumgärtner
Researcher at University of Veterinary Medicine Vienna
Publications - 374
Citations - 10019
Wolfgang Baumgärtner is an academic researcher from University of Veterinary Medicine Vienna. The author has contributed to research in topics: Virus & Canine distemper. The author has an hindex of 46, co-authored 323 publications receiving 8177 citations. Previous affiliations of Wolfgang Baumgärtner include University of Giessen & Hochschule Hannover.
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Journal ArticleDOI
Astrocytes regulate myelin clearance through recruitment of microglia during cuprizone-induced demyelination
Thomas Skripuletz,Diane Hackstette,Katharina Bauer,Viktoria Gudi,Refik Pul,Elke Voss,Katharina Berger,Markus Kipp,Wolfgang Baumgärtner,Martin Stangel +9 more
TL;DR: Data demonstrate for the first time in vivo that astrocytes provide the signal environment that forms the basis for the recruitment of microglia to clear myelin debris, a process required for subsequent repair mechanisms in demyelinating diseases such as multiple sclerosis.
Journal ArticleDOI
Pathogenesis and immunopathology of systemic and nervous canine distemper.
TL;DR: DL represents a biphasic disease process consisting of an initial direct virus-mediated process and immune-mediated plaque progression, and an altered balance between matrix metalloproteinases and their inhibitors seems to play a pivotal role for the pathogenesis of DL.
Journal ArticleDOI
Detection of Canine Distemper Virus Nucleoprotein RNA by Reverse Transcription-PCR Using Serum, Whole Blood, and Cerebrospinal Fluid from Dogs with Distemper
TL;DR: Although the sensitivity of the RT-PCR for detection of CDV is strongly influenced by the location of the selected primers, this nucleic acid detection system represents a highly specific and sensitive method for the antemortem diagnosis of Distemper in dogs, regardless of the form of distemper, humoral immune response, and viral antigen distribution.
Journal ArticleDOI
An orthopoxvirus-based vaccine reduces virus excretion after MERS-CoV infection in dromedary camels
Bart L. Haagmans,Judith M. A. van den Brand,V. Stalin Raj,Asisa Volz,Peter Wohlsein,Saskia L. Smits,Debby Schipper,Theo M. Bestebroer,Nisreen M.A. Okba,Robert Fux,Albert Bensaid,David Solanes Foz,Thijs Kuiken,Wolfgang Baumgärtner,Joaquim Segalés,Gerd Sutter,Albert D. M. E. Osterhaus,Albert D. M. E. Osterhaus,Albert D. M. E. Osterhaus +18 more
TL;DR: It is shown that a modified vaccinia virus Ankara (MVA) vaccine expressing the MERS-CoV spike protein confers mucosal immunity in dromedary camels, and that induction of MVA-specific antibodies that cross-neutralize camelpox virus would also provide protection against camelpox.
Journal ArticleDOI
Neurotropic virus infections as the cause of immediate and delayed neuropathology.
Martin Ludlow,Jeroen Kortekaas,Christiane Herden,Bernd Hoffmann,Dennis Tappe,Corinna Trebst,Diane E. Griffin,Hannah Brindle,Tom Solomon,Alan S. Brown,Debby van Riel,Katja C. Wolthers,Dasja Pajkrt,Peter Wohlsein,Byron E. E. Martina,Wolfgang Baumgärtner,Georges M. G. M. Verjans,Georges M. G. M. Verjans,Albert D. M. E. Osterhaus,Albert D. M. E. Osterhaus +19 more
TL;DR: Mechanisms that govern neuropathogenesis and immunopathogenesis of viral infections are highlighted, using examples of well-studied virus infections that are associated with these alterations in different populations throughout the world.