G
Gerald F. Späth
Researcher at Pasteur Institute
Publications - 92
Citations - 5071
Gerald F. Späth is an academic researcher from Pasteur Institute. The author has contributed to research in topics: Leishmania & Leishmania major. The author has an hindex of 34, co-authored 82 publications receiving 4513 citations. Previous affiliations of Gerald F. Späth include French Institute of Health and Medical Research & New York University.
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Journal ArticleDOI
A Lipophosphoglycan-Independent Method for Isolation of Infective Leishmania Metacyclic Promastigotes by Density Gradient Centrifugation
TL;DR: A simple density gradient centrifugation method is described, which allows the rapid purification of infective metacyclic parasites from both wild-type and LPG-deficient Leishmania major and suggests that this method is applicable to other LeishMania species including L. donovani.
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Lipophosphoglycan is a virulence factor distinct from related glycoconjugates in the protozoan parasite Leishmania major
Gerald F. Späth,Linda F. Epstein,Ben Leader,Steven M. Singer,Herbert A. Avila,Salvatore J. Turco,Stephen M. Beverley +6 more
TL;DR: Genetic approaches allow dissection of the roles of this complex family of interrelated parasite virulence factors, and definitively establish the role of LPG itself as a parasite virulent factor.
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The role(s) of lipophosphoglycan (LPG) in the establishment of Leishmania major infections in mammalian hosts
TL;DR: The value of mechanistic approaches focusing on both parasite and host defense pathways in dissecting the specific biological roles of complex virulence factors such as LPG is illustrated.
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The role of phosphoglycans in Leishmania–sand fly interactions
David L. Sacks,Govind B. Modi,Edgar Rowton,Gerald F. Späth,Linda F. Epstein,Salvatore J. Turco,Stephen M. Beverley +6 more
TL;DR: LPG is not essential for survival in the early blood-fed midgut but, along with other secreted phosphoglycan-containing glycoconjugates, can protect promastigotes from the digestive enzymes in the gut and, second, that LPG is required to mediate midGut attachment and to maintain infection in the fly during excretion of the digested blood meal.
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Protein Kinase C θ Is Critical for the Development of In Vivo T Helper (Th)2 Cell But Not Th1 Cell Responses
TL;DR: It is found that pkc-θ− / − mice were protected from pulmonary allergic hypersensitivity responses such as airway hyperresponsiveness, eosinophilia, and immunoglobulin E production to inhaled allergen, and a central role for PKC- θ signaling during Th2 responses is revealed.