Gerald Mueller

TL;DR: The present results indicate that a knock-out of GSHPx may be adequately compensated under nonstressed conditions, but that after administration of mitochondrial toxins GSHpx plays an important role in detoxifying increases in oxygen radicals.

TL;DR: It was found that oral administration of creatine produced a dose-dependent improvement in motor performance and extended survival in G93A transgenic mice, and it protected mice from loss of both motor neurons and substantia nigra neurons at 120 days of age.

TL;DR: Oral supplementation with either creatine or cyclocreatine produced significant protection against MPTP-induced dopamine depletions in mice, and this results further implicate metabolic dysfunction in MPTP neurotoxicity and suggest a novel therapeutic approach, which may have applicability for Parkinson's disease.

TL;DR: It is found that following administration of the mitochondrial toxin 3-nitropropionic acid, there was a significant increase in the conversion of 4-hydroxybenzoic acid to 3,4-dihydroxybenzosic acid in control mice, but not in Bcl-2 overexpressing mice, which shows that Bcl -2 overexpression in vivo attenuates the generation of reactive oxygen species.

TL;DR: Findings provide further evidence that free radical spin traps produce neuroprotective effects in vivo and suggest that they may be useful in the treatment of neurodegenerative diseases.