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Péter Klivényi
Researcher at University of Szeged
Publications - 218
Citations - 8770
Péter Klivényi is an academic researcher from University of Szeged. The author has contributed to research in topics: Medicine & Neuroprotection. The author has an hindex of 39, co-authored 187 publications receiving 8074 citations. Previous affiliations of Péter Klivényi include Cornell University & Harvard University.
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Journal ArticleDOI
Mice Deficient in Cellular Glutathione Peroxidase Show Increased Vulnerability to Malonate, 3-Nitropropionic Acid, and 1-Methyl-4-Phenyl-1,2,5,6-Tetrahydropyridine
Péter Klivényi,Ole A. Andreassen,Robert J. Ferrante,Alpaslan Dedeoglu,Gerald Mueller,Eric Lancelot,Mikhail B. Bogdanov,Julie K. Andersen,Dongmei Jiang,M. Flint Beal,M. Flint Beal +10 more
TL;DR: The present results indicate that a knock-out of GSHPx may be adequately compensated under nonstressed conditions, but that after administration of mitochondrial toxins GSHpx plays an important role in detoxifying increases in oxygen radicals.
Journal ArticleDOI
Neuroprotective effects of creatine in a transgenic animal model of amyotrophic lateral sclerosis
Péter Klivényi,Robert J. Ferrante,Robert J. Ferrante,Russell T. Matthews,Mikhail B. Bogdanov,Autumn M. Klein,Autumn M. Klein,Ole A. Andreassen,Gerald Mueller,Marike Wermer,Rima Kaddurah-Daouk,M F Beal,M F Beal +12 more
TL;DR: It was found that oral administration of creatine produced a dose-dependent improvement in motor performance and extended survival in G93A transgenic mice, and it protected mice from loss of both motor neurons and substantia nigra neurons at 120 days of age.
Journal ArticleDOI
Neural subtype specification of fertilization and nuclear transfer embryonic stem cells and application in parkinsonian mice.
Tiziano Barberi,Péter Klivényi,Noel Y. Calingasan,Hyojin Lee,Hibiki Kawamata,Kathleen Loonam,Anselme L. Perrier,Juan Bruses,Maria E. Rubio,Norbert Topf,Viviane Tabar,Neil L. Harrison,M. Flint Beal,Malcolm A.S. Moore,Lorenz Studer +14 more
TL;DR: A set of coculture conditions is provided that allows rapid and efficient derivation of most central nervous system phenotypes and transplantation of ES and ntES cell–derived dopaminergic neurons corrected the phenotype of a mouse model of Parkinson disease, demonstrating an in vivo application of therapeutic cloning in neural disease.
Journal ArticleDOI
Neuroprotective Effects of Phenylbutyrate in the N171-82Q Transgenic Mouse Model of Huntington's Disease
Gabriella Gárdián,Susan E. Browne,Dong-Kug Choi,Péter Klivényi,Jason Gregorio,James K. Kubilus,James K. Kubilus,Hoon Ryu,Hoon Ryu,Brett Langley,Rajiv R. Ratan,Rajiv R. Ratan,Robert J. Ferrante,Robert J. Ferrante,M. Flint Beal +14 more
TL;DR: Results show that administration of phenylbutyrate, at doses that are well tolerated in man, exerts significant neuroprotective effects in a transgenic mouse model of HD, and therefore represents a very promising therapeutic approach for HD.
Journal ArticleDOI
The Alzheimer's Association external quality control program for cerebrospinal fluid biomarkers
Niklas Mattsson,Ulf Andreasson,Staffan Persson,Hiroyuki Arai,Sat Dev Batish,Sergio Bernardini,Luisella Bocchio-Chiavetto,Marinus A. Blankenstein,Maria Berrocal Carrillo,Sonia Chalbot,Els Coart,Davide Chiasserini,Neal Cutler,Gunilla Dahlfors,Stefan Duller,Anne M. Fagan,Orestes Vicente Forlenza,Giovanni B. Frisoni,Douglas Galasko,Daniela Galimberti,Harald Hampel,Aase Handberg,Michael T. Heneka,Adrianna Z. Herskovits,Sanna-Kaisa Herukka,David M. Holtzman,Christian Humpel,Bradley T. Hyman,Khalid Iqbal,Mathias Jucker,Stephan A. Kaeser,Elmar Kaiser,Elisabeth Kapaki,Daniel Kidd,Péter Klivényi,Cindy Soendersoe Knudsen,Markus P. Kummer,James Lui,Albert Lladó,Piotr Lewczuk,Qiao-Xin Li,Ralph N. Martins,Colin L. Masters,John McAuliffe,Marc Mercken,Abhay Moghekar,José Luis Molinuevo,Thomas J. Montine,William Nowatzke,Richard O'Brien,Markus Otto,George P. Paraskevas,Lucilla Parnetti,Ronald C. Petersen,David Prvulovic,Herman P M de Reus,Robert A. Rissman,Elio Scarpini,Alessandro Stefani,Hilkka Soininen,Johannes Schröder,Leslie M. Shaw,Anders Skinningsrud,Brith Skrogstad,Annette Spreer,Leda Leme Talib,Charlotte E. Teunissen,John Q. Trojanowski,Hayrettin Tumani,Robert M. Umek,Bianca Van Broeck,Hugo Vanderstichele,László Vécsei,Marcel M. Verbeek,Manfred Windisch,Jing Zhang,Henrik Zetterberg,Kaj Blennow +77 more
TL;DR: The cerebrospinal fluid biomarkers amyloid β (Aβ)‐42, total‐Tau (T‐tau), and phosphorylated‐t Tau (P‐tAU) demonstrate good diagnostic accuracy for Alzheimer's disease (AD), but there are large variations in biomarker measurements between studies, and between and within laboratories.