G
Gerard Brennan
Researcher at Queen's University Belfast
Publications - 84
Citations - 3979
Gerard Brennan is an academic researcher from Queen's University Belfast. The author has contributed to research in topics: Fasciola hepatica & Triclabendazole. The author has an hindex of 31, co-authored 84 publications receiving 3675 citations.
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Journal ArticleDOI
Polyethylene multiwalled carbon nanotube composites
Tony McNally,Petra Pötschke,Peter J. Halley,Michael Murphy,Darren J. Martin,Steven E. J. Bell,Gerard Brennan,Daniel Bein,Patrick Lemoine,JP Quinn +9 more
TL;DR: In this article, the electrical conductivity and linear viscoelastic behavior of polyethylene (PE) multiwalled carbon nanotubes (MWCNTs) with weight fractions ranging from 0.1 to 10 wt% were prepared by melt blending using a mini-twin screw extruder.
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Fasciola hepatica cathepsin L-like proteases: biology, function, and potential in the development of first generation liver fluke vaccines.
John P. Dalton,Sandra O Neill,Colin M. Stack,Peter R. Collins,Alan Walshe,Mary Sekiya,Sean Doyle,Grace Mulcahy,Grace Mulcahy,Deborah V. Hoyle,Eric Khaznadji,Nathalie Moiré,Gerard Brennan,Angela Mousley,Natalia D. Kreshchenko,Aaron G. Maule,Sheila Donnelly +16 more
TL;DR: The role of antibody and T cell responses in mediating protection and the prospects of the cathepsin Ls in the development of first generation recombinant liver fluke vaccines are reviewed.
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Polyamide-12 layered silicate nanocomposites by melt blending
TL;DR: In this paper, the nanocomposite morphology and clay dispersion were investigated using wide angle X-ray diffraction (XRD), scanning electron microscopy (SEM), SEM-energy dispersive Xray analysis, SEM-EDX, transmission electron miscroscopy (TEM), high resolution transmission electron microscope (HRTEM) and atomic force microscopy(AFM) and showed that a predominantly intercalated morphology was observed for polyamide-12-ME100, and a very high degree of exfoliation for PA12-MAE.
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The silencing of cysteine proteases in Fasciola hepatica newly excysted juveniles using RNA interference reduces gut penetration
Louise McGonigle,Angela Mousley,Nikki J. Marks,Gerard Brennan,John P. Dalton,Terry W. Spithill,Terry W. Spithill,Tim A. Day,Aaron G. Maule +8 more
TL;DR: The successful silencing of the cysteine proteases cathepsin B and L in the infective stage of Fasciola hepatica newly excysted juveniles (NEJs) resulted in marked reductions in target transcript levels and significant diminution in the encoded proteins in the gut.
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Purification of a cathepsin L-like proteinase secreted by adult Fasciola hepatica
Angela M. Smith,Andrew J. Dowd,Sharon McGonigle,Paul S. Keegan,Gerard Brennan,Alan Trudgett,John P. Dalton +6 more
TL;DR: Immunolocalisation studies revealed that the cathepsin L-like proteinase is concentrated within vesicles in the gut epithelial cells of liver fluke.