J
John P. Dalton
Researcher at National University of Ireland, Galway
Publications - 251
Citations - 13834
John P. Dalton is an academic researcher from National University of Ireland, Galway. The author has contributed to research in topics: Fasciola hepatica & Cathepsin L. The author has an hindex of 66, co-authored 239 publications receiving 12553 citations. Previous affiliations of John P. Dalton include Queen's University Belfast & BlackRock.
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Book ChapterDOI
Proteinases and associated genes of parasitic helminths
TL;DR: Information on proteinases from trematodes, cestodes and nematode parasites is reviewed, concentrating on those worms of major medical and economical importance, and a phylogenetic analysis of the papain superfamily of cysteine proteinases is devoted.
Journal ArticleDOI
Fasciola hepatica cathepsin L-like proteases: biology, function, and potential in the development of first generation liver fluke vaccines.
John P. Dalton,Sandra O Neill,Colin M. Stack,Peter R. Collins,Alan Walshe,Mary Sekiya,Sean Doyle,Grace Mulcahy,Grace Mulcahy,Deborah V. Hoyle,Eric Khaznadji,Nathalie Moiré,Gerard Brennan,Angela Mousley,Natalia D. Kreshchenko,Aaron G. Maule,Sheila Donnelly +16 more
TL;DR: The role of antibody and T cell responses in mediating protection and the prospects of the cathepsin Ls in the development of first generation recombinant liver fluke vaccines are reviewed.
Journal ArticleDOI
An Integrated Transcriptomics and Proteomics Analysis of the Secretome of the Helminth Pathogen Fasciola hepatica: PROTEINS ASSOCIATED WITH INVASION AND INFECTION OF THE MAMMALIAN HOST*
TL;DR: Proteomics analysis of proteins secreted by infective larvae, immature flukes, and adult F. hepatica showed that these proteases are developmentally regulated and correlate with the passage of the parasite through host tissues and its encounters with different host macromolecules.
Journal ArticleDOI
Thioredoxin Peroxidase Secreted by Fasciola hepatica Induces the Alternative Activation of Macrophages
TL;DR: The data suggest that the Th2 responses induced by the helminth F. hepatica are mediated through the secretion of molecules, one of which is TPx, that induce the recruitment and alternative activation of macrophages.
Journal ArticleDOI
Induction of protective immunity in cattle against infection with Fasciola hepatica by vaccination with cathepsin L proteinases and with hemoglobin.
TL;DR: The results of these trials demonstrate that cathepsin Ls and Hb could form the basis of a molecular vaccine that would not only reduce parasite burden but would also prevent transmission of liver fluke disease.