T
Tim A. Day
Researcher at Iowa State University
Publications - 98
Citations - 5737
Tim A. Day is an academic researcher from Iowa State University. The author has contributed to research in topics: Schistosoma mansoni & Muscle contraction. The author has an hindex of 34, co-authored 98 publications receiving 5205 citations. Previous affiliations of Tim A. Day include McGill University & Michigan State University.
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Journal ArticleDOI
The genome of the blood fluke Schistosoma mansoni
Matthew Berriman,Brian J. Haas,Brian J. Haas,Philip T. LoVerde,R. Alan Wilson,Gary P. Dillon,Gustavo C. Cerqueira,Susan T. Mashiyama,Bissan Al-Lazikani,Luiza F. Andrade,Peter D. Ashton,Martin Aslett,Daniella Castanheira Bartholomeu,Daniella Castanheira Bartholomeu,Gaëlle Blandin,Conor R. Caffrey,Avril Coghlan,Richard M.R. Coulson,Tim A. Day,Arthur L. Delcher,Ricardo DeMarco,Ricardo DeMarco,Appoliniare Djikeng,Tina Eyre,John Gamble,Elodie Ghedin,Elodie Ghedin,Yong-Hong Gu,Christiane Hertz-Fowler,Hirohisha Hirai,Yuriko Hirai,Robin Houston,Alasdair Ivens,David A. Johnston,David A. Johnston,Daniela R. Lacerda,Daniela R. Lacerda,Camila D. S. Macedo,Paul McVeigh,Zemin Ning,Guilherme Oliveira,John P. Overington,Julian Parkhill,Mihaela Pertea,Raymond J. Pierce,Anna V. Protasio,Michael A. Quail,Marie-Adèle Rajandream,Jane Rogers,Mohammed Sajid,Steven L. Salzberg,Mario Stanke,Adrian Tivey,Owen White,Owen White,David L. Williams,David L. Williams,Jennifer R. Wortman,Jennifer R. Wortman,Wenjie Wu,Mostafa Zamanian,Adhemar Zerlotini,Claire M. Fraser-Liggett,Claire M. Fraser-Liggett,Barclay G. Barrell,Najib M. El-Sayed,Najib M. El-Sayed +66 more
TL;DR: Analysis of the 363 megabase nuclear genome of the blood fluke, the first sequenced flatworm, and a representative of the Lophotrochozoa offers insights into early events in the evolution of the animals, including the development of a body pattern with bilateral symmetry, and theDevelopment of tissues into organs.
Journal ArticleDOI
The genomes of four tapeworm species reveal adaptations to parasitism
Isheng J. Tsai,Magdalena Zarowiecki,Nancy Holroyd,Alejandro Garciarrubio,Alejandro Sanchez-Flores,Karen Brooks,Alan Tracey,Raúl J. Bobes,Gladis Fragoso,Edda Sciutto,Martin Aslett,Helen Beasley,Hayley M. Bennett,Jianping Cai,Federico Camicia,Richard Clark,Marcela Alejandra Cucher,Nishadi De Silva,Tim A. Day,Peter Deplazes,Karel Estrada,Cecilia Fernández,Peter W. H. Holland,Junling Hou,Songnian Hu,Thomas Huckvale,Stacy S. Hung,Laura Kamenetzky,Jacqueline A. Keane,Ferenc Kiss,Uriel Koziol,Olivia Lambert,Kan Liu,Xuenong Luo,Yingfeng Luo,Natalia Macchiaroli,Sarah Nichol,Jordi Paps,John Parkinson,Natasha Pouchkina-Stantcheva,Nick Riddiford,Mara Cecilia Rosenzvit,Gustavo Salinas,James D. Wasmuth,Mostafa Zamanian,Yadong Zheng,Xuepeng Cai,Xavier Soberón,Peter D. Olson,Juan Pedro Laclette,Klaus Brehm,Matthew Berriman +51 more
TL;DR: An analysis of tapeworm genome sequences using the human-infective species Echinococcus multilocularis, E. granulosus, Taenia solium and the laboratory model Hymenolepis microstoma offers insights into the evolution of parasitism and identifies new potential drug targets.
Journal ArticleDOI
Resistance to praziquantel: direct evidence from Schistosoma mansoni isolated from Egyptian villagers.
Ismail Mm,Sanaa S. Botros,Aiesha Metwally,Samia William,Adel Farghally,Liang-Fang Tao,Tim A. Day,James L. Bennett +7 more
TL;DR: It is concluded that the in vitro action of the drug is related to its in vivo action and this relationship will assist in the ability to detect or survey for the PZQ resistant phenotype in human populations.
Journal ArticleDOI
Comparative genomics of the major parasitic worms
TL;DR: A broad comparative study of 81 genomes of parasitic and non-parasitic worms identifies gene family births and hundreds of expanded gene families at key nodes in the phylogeny that are relevant to parasitism and proteins historically targeted for drug development.
Journal ArticleDOI
The silencing of cysteine proteases in Fasciola hepatica newly excysted juveniles using RNA interference reduces gut penetration
Louise McGonigle,Angela Mousley,Nikki J. Marks,Gerard Brennan,John P. Dalton,Terry W. Spithill,Terry W. Spithill,Tim A. Day,Aaron G. Maule +8 more
TL;DR: The successful silencing of the cysteine proteases cathepsin B and L in the infective stage of Fasciola hepatica newly excysted juveniles (NEJs) resulted in marked reductions in target transcript levels and significant diminution in the encoded proteins in the gut.