G
Gérard Jaouen
Researcher at Chimie ParisTech
Publications - 384
Citations - 12935
Gérard Jaouen is an academic researcher from Chimie ParisTech. The author has contributed to research in topics: Bioorganometallic chemistry & Cyclopentadienyl complex. The author has an hindex of 55, co-authored 378 publications receiving 12170 citations. Previous affiliations of Gérard Jaouen include University of Paris & PSL Research University.
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Ferrocifen type anti cancer drugs.
TL;DR: It is shown here the different antitumoral approaches offered by ferrocifen derivatives, originally simple derivatives of tamoxifen, which over the course of their development have proved to possess remarkable structural and mechanistic diversity.
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Ferrocene‐Mediated Proton‐Coupled Electron Transfer in a Series of Ferrocifen‐Type Breast‐Cancer Drug Candidates
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Synthesis, biochemical properties and molecular modelling studies of organometallic specific estrogen receptor modulators (SERMs), the ferrocifens and hydroxyferrocifens: evidence for an antiproliferative effect of hydroxyferrocifens on both hormone-dependent and hormone-independent breast cancer cell lines.
Siden Top,Anne Vessières,Guy Leclercq,Jacques Quivy,Jie Tang,Jacqueline Vaissermann,Michel Huché,Gérard Jaouen +7 more
TL;DR: The molecular modelling study provides some clues for understanding of the antagonist effect of these molecules, while an additional cytotoxic effect due to the vectorised ferrocenyl unit is revealed in some occasions.
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Bioorganometallic chemistry: Structural diversity of organometallic complexes with bioligands and molecular recognition studies of several supramolecular hosts with biomolecules, alkali-metal ions, and organometallic pharmaceuticals
TL;DR: This review shows the various novel structures with bioligands of other colleagues, as well as those from the authors' own studies, including organometallic ionophores for selective recognition of alkali-metal ions.