Gerard Pujadas

TL;DR: This review focuses on commonly used fingerprint algorithms, their usage in virtual screening, and the software packages and online tools that provide these algorithms.

TL;DR: A beneficial effect of PE on low-grade inflammatory diseases, which may be associated with the inhibition of the proinflammatory molecules CRP, IL-6 and TNF-alpha and the enhanced production of the anti-inflammatory cytokine adiponectin is suggested.

TL;DR: The results suggest that flavonoids are an excellent source of functional antihypertensive products and the structure-activity relationship studies show that the combination of sub-structures on the flavonoid skeleton that increase ACEI activity is made up of the catechol group in the B-ring and the cetone group in C4 at the C-ring.

TL;DR: PE modulates inflammatory response in activated macrophages by the inhibition of NO and PGE2 production, suppression of iNOS expression, and NFkB translocation, demonstrating an immunomodulatory role of grape seed procyanidins and thus a potential health-benefit in inflammatory conditions that exert an overproduction of NO.

TL;DR: Oral ingested PE helps preventing imbalanced obesity cytokine pattern, but its corrective effects need to be further investigated.