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Anna Ardévol
Researcher at Rovira i Virgili University
Publications - 128
Citations - 5124
Anna Ardévol is an academic researcher from Rovira i Virgili University. The author has contributed to research in topics: Adipose tissue & Insulin. The author has an hindex of 37, co-authored 117 publications receiving 4473 citations. Previous affiliations of Anna Ardévol include Generalitat of Catalonia & Hammersmith Hospital.
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Grape seed-derived procyanidins have an antihyperglycemic effect in streptozotocin-induced diabetic rats and insulinomimetic activity in insulin-sensitive cell lines.
TL;DR: Procyanidins have insulin-like effects in insulin-sensitive cells that could help to explain their antihyperglycemic effect in vivo, which was significantly increased if PE administration was accompanied by a low insulin dose.
Journal ArticleDOI
Grape-seed procyanidins prevent low-grade inflammation by modulating cytokine expression in rats fed a high-fat diet.
Ximena Terra,Gemma Montagut,Mario Bustos,Niurka Llópiz,Anna Ardévol,Cinta Bladé,Juan Fernández-Larrea,Gerard Pujadas,Josepa Salvadó,Lluís Arola,Mayte Blay +10 more
TL;DR: A beneficial effect of PE on low-grade inflammatory diseases, which may be associated with the inhibition of the proinflammatory molecules CRP, IL-6 and TNF-alpha and the enhanced production of the anti-inflammatory cytokine adiponectin is suggested.
Journal ArticleDOI
Grape-seed Procyanidins Act as Antiinflammatory Agents in Endotoxin-Stimulated RAW 264.7 Macrophages by Inhibiting NFkB Signaling Pathway
Ximena Terra,Josep Valls,X. Vitrac,Jean-Michel Mérrillon,Lluís Arola,Anna Ardévol,Cinta Bladé,Juan Fernández-Larrea,Gerard Pujadas,Josepa Salvadó,Mayte Blay +10 more
TL;DR: PE modulates inflammatory response in activated macrophages by the inhibition of NO and PGE2 production, suppression of iNOS expression, and NFkB translocation, demonstrating an immunomodulatory role of grape seed procyanidins and thus a potential health-benefit in inflammatory conditions that exert an overproduction of NO.
Journal ArticleDOI
Grape seed procyanidins improve atherosclerotic risk index and induce liver CYP7A1 and SHP expression in healthy rats
Josep M. del Bas,Juan Fernández-Larrea,Mayte Blay,Anna Ardévol,Maria Josepa Salvadó,Lluís Arola,Cinta Bladé +6 more
TL;DR: Procyanidins improve the atherosclerotic risk index in the postprandial state, inducing in the liver the overexpression of CYP7A1 (suggesting an increase of cholesterol elimination via bile acids) and SHP, a nuclear receptor emerging as a key regulator of lipid homeostasis at the transcriptional level.
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Grape Seed Procyanidins Prevent Oxidative Injury by Modulating the Expression of Antioxidant Enzyme Systems
TL;DR: It is hypothesized that GSPE probably improves the cellular redox status via glutathione synthesis pathways instead of regulation of the GPx and/or GR activities protecting against oxidative damage.