G
Gerd Wallukat
Researcher at Max Delbrück Center for Molecular Medicine
Publications - 252
Citations - 12575
Gerd Wallukat is an academic researcher from Max Delbrück Center for Molecular Medicine. The author has contributed to research in topics: Receptor & Angiotensin II. The author has an hindex of 58, co-authored 241 publications receiving 11402 citations. Previous affiliations of Gerd Wallukat include Humboldt University of Berlin.
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Journal ArticleDOI
Patients with preeclampsia develop agonistic autoantibodies against the angiotensin AT1 receptor.
Gerd Wallukat,Volker Homuth,Thorsten Fischer,Carsten Lindschau,Björn Horstkamp,Axel Jüpner,Evi Baur,Eberhard Nissen,Klaus Vetter,Dajana Neichel,Joachim W. Dudenhausen,Hermann Haller,Friedrich C. Luft +12 more
TL;DR: It is suggested that preeclamptic patients develop stimulatory autoantibodies against the second extracellular AT1 receptor loop, which appears to be PKC-mediated and may participate in the angiotensin II-induced vascular lesions in these patients.
Journal ArticleDOI
Angiotensin II type 1-receptor activating antibodies in renal-allograft rejection.
Duska Dragun,Dominik N. Müller,Jan Hinrich Bräsen,Lutz Fritsche,Melina Nieminen-Kelhä,Ralf Dechend,Ulrich Kintscher,Birgit Rudolph,Johan Hoebeke,Diana Eckert,Istvan Mazak,Ralph Plehm,Constanze Schönemann,Thomas Unger,Klemens Budde,Hans-Hellmut Neumayer,Friedrich C. Luft,Gerd Wallukat +17 more
TL;DR: A non-HLA, AT1-receptor-mediated pathway may contribute to refractory vascular rejection, and affected patients might benefit from removal of At1- receptor antibodies or from pharmacologic blockade of AT1 receptors.
Journal ArticleDOI
Arachidonic Acid-metabolizing Cytochrome P450 Enzymes Are Targets of ω-3 Fatty Acids
Cosima Arnold,Marija Markovic,Katrin Blossey,Gerd Wallukat,Robert Fischer,Ralf Dechend,Anne Konkel,Clemens von Schacky,Friedrich C. Luft,Friedrich C. Luft,Dominik N. Müller,Michael Rothe,Wolf-Hagen Schunck +12 more
TL;DR: It is found that these ω-3 epoxides are highly active as antiarrhythmic agents, suppressing the Ca2+-induced increased rate of spontaneous beating of neonatal rat cardiomyocytes, at low nanomolar concentrations.
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Weaning From Mechanical Cardiac Support in Patients With Idiopathic Dilated Cardiomyopathy
Johannes Müller,Gerd Wallukat,Yu Guo Weng,Michael Dandel,Susanne Spiegelsberger,Sabine Semrau,Kersten Brandes,Vassilis Theodoridis,Matthias Loebe,Rudolf Meyer,Roland Hetzer +10 more
TL;DR: In this article, the authors report long-term effects of ventricular unloading on cardiac function, humoral anti-β1-adrenoceptor autoantibodies (A-β 1-AABs), and myocardial fibrosis.
Journal ArticleDOI
Immunoglobulin Adsorption in Patients With Idiopathic Dilated Cardiomyopathy
Johannes Müller,Gerd Wallukat,Michael Dandel,Heidrun Bieda,Kersten Brandes,Susanne Spiegelsberger,Eberhard Nissen,Rudolf Kunze,Roland Hetzer +8 more
TL;DR: In IDC, theUse of immunoadsorption is superior to the use of standard medical therapy and significantly improves cardiac performance and clinical status.